2. Anti-infection
  3. Influenza Virus
  4. ML303

ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1.

For research use only. We do not sell to patients.

ML303 Chemical Structure

ML303 Chemical Structure

CAS No. : 1638211-04-7

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5 mg USD 120 In-stock
10 mg USD 180 In-stock
25 mg USD 330 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

ML303 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].

IC50 & Target

EC50: 0.7 μM (H1N1)[1].
Cellular Effect
Cell Line Type Value Description References
MDCK CC50
19.8 μM
Compound: 32
Cytotoxicity against MDCK cells assessed as reduction in cell viability measured on day 5 by Celltiter-Glo luminescence assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability measured on day 5 by Celltiter-Glo luminescence assay
[PMID: 30852083]
In Vitro

ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ML303 Related Antibodies

Western Blot Analysis[1]

Cell Line: MDCK cells infected with A/PR/8/34, at a MOI of 2, for 6 hours.
Concentration: 20 μM.
Incubation Time: 6 hours.
Result: Restored IFN-β mRNA levels in MDCK cells.
Molecular Weight

399.37

Formula

C21H16F3N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(C2=CC=NC3=C2C(C)=NN3C4=CC=C(C(F)(F)F)C=C4)C=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (312.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5039 mL 12.5197 mL 25.0394 mL
5 mM 0.5008 mL 2.5039 mL 5.0079 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.62%

SDS (251 KB)

COA (250 KB) HNMR (270 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5039 mL 12.5197 mL 25.0394 mL 62.5986 mL
5 mM 0.5008 mL 2.5039 mL 5.0079 mL 12.5197 mL
10 mM 0.2504 mL 1.2520 mL 2.5039 mL 6.2599 mL
15 mM 0.1669 mL 0.8346 mL 1.6693 mL 4.1732 mL
20 mM 0.1252 mL 0.6260 mL 1.2520 mL 3.1299 mL
25 mM 0.1002 mL 0.5008 mL 1.0016 mL 2.5039 mL
30 mM 0.0835 mL 0.4173 mL 0.8346 mL 2.0866 mL
40 mM 0.0626 mL 0.3130 mL 0.6260 mL 1.5650 mL
50 mM 0.0501 mL 0.2504 mL 0.5008 mL 1.2520 mL
60 mM 0.0417 mL 0.2087 mL 0.4173 mL 1.0433 mL
80 mM 0.0313 mL 0.1565 mL 0.3130 mL 0.7825 mL
100 mM 0.0250 mL 0.1252 mL 0.2504 mL 0.6260 mL
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ML303 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML3031638211-04-7ML 303ML-303Influenza VirusInhibitorinhibitorinhibit

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