2. MAPK/ERK Pathway
  3. Mixed Lineage Kinase
  4. MLK-IN-1

MLK-IN-1 is a potent, brain penetrant and specific mixed lineage kinase 3 (MLK-3) inhibitor, compound 68, extracted from patent US20140256733A1.

For research use only. We do not sell to patients.

MLK-IN-1 Chemical Structure

MLK-IN-1 Chemical Structure

CAS No. : 1627729-62-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 385 In-stock
Solution
10 mM * 1 mL in DMSO USD 385 In-stock
Solid
1 mg USD 140 In-stock
5 mg USD 350 In-stock
10 mg USD 560 In-stock
25 mg USD 1130 In-stock
50 mg USD 1800 In-stock
100 mg USD 2900 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

MLK-IN-1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MLK-IN-1 is a potent, brain penetrant and specific mixed lineage kinase 3 (MLK-3) inhibitor, compound 68, extracted from patent US20140256733A1[1].

In Vitro

MLK-IN-1 (100 nM; pre-treatment 20 mins HIV-1 Tat) promotes continued axonogenesis in the presence of Tat-activated microglia and protects against effects of HIV-Tat in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MLK-IN-1 Related Antibodies
Molecular Weight

432.49

Formula

C23H20N4O3S
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

COC1=C2C(C=C(C3=CN=C4C=CC(NC5=CC=C(OC)C(OC)=C5)=NN43)S2)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (144.51 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3122 mL 11.5610 mL 23.1219 mL
5 mM 0.4624 mL 2.3122 mL 4.6244 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3122 mL 11.5610 mL 23.1219 mL 57.8048 mL
5 mM 0.4624 mL 2.3122 mL 4.6244 mL 11.5610 mL
10 mM 0.2312 mL 1.1561 mL 2.3122 mL 5.7805 mL
15 mM 0.1541 mL 0.7707 mL 1.5415 mL 3.8537 mL
20 mM 0.1156 mL 0.5780 mL 1.1561 mL 2.8902 mL
25 mM 0.0925 mL 0.4624 mL 0.9249 mL 2.3122 mL
30 mM 0.0771 mL 0.3854 mL 0.7707 mL 1.9268 mL
40 mM 0.0578 mL 0.2890 mL 0.5780 mL 1.4451 mL
50 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1561 mL
60 mM 0.0385 mL 0.1927 mL 0.3854 mL 0.9634 mL
80 mM 0.0289 mL 0.1445 mL 0.2890 mL 0.7226 mL
100 mM 0.0231 mL 0.1156 mL 0.2312 mL 0.5780 mL
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MLK-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MLK-IN-11627729-62-7Mixed Lineage KinaseMLKsimidazopyridineAxonogenesismicrogliaE18primaryhippocampal neuronHIV-TataxonogenesisInhibitorinhibitorinhibit

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