2. PROTAC Epigenetics
  3. Molecular Glues Epigenetic Reader Domain
  4. MMH2

MMH2 is a novel BRD4 molecular glue degrader that functions by recruiting the CUL4 and DCAF16 ligases to the second bromodomain of BRD4 (BRD4BD2).

For research use only. We do not sell to patients.

MMH2 Chemical Structure

MMH2 Chemical Structure

Size Price Stock Quantity
5 mg USD 705 In-stock
10 mg USD 1200 In-stock
25 mg USD 2160 In-stock
50 mg USD 3024 In-stock
100 mg USD 4230 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

MMH2 Related Antibodies

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Description

MMH2 is a novel BRD4 molecular glue degrader that functions by recruiting the CUL4 and DCAF16 ligases to the second bromodomain of BRD4 (BRD4BD2)[1].

IC50 & Target

BRD4

 

Molecular Weight

527.66

Formula

C25H29N5O4S2
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=C(C)SC2=C1C(C3=CC=C(NS(C=C)(=O)=O)C=C3)=N[C@@H](CC(OC(C)(C)C)=O)C4=NN=C(C)N42
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (189.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8952 mL 9.4758 mL 18.9516 mL
5 mM 0.3790 mL 1.8952 mL 3.7903 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8952 mL 9.4758 mL 18.9516 mL 47.3790 mL
5 mM 0.3790 mL 1.8952 mL 3.7903 mL 9.4758 mL
10 mM 0.1895 mL 0.9476 mL 1.8952 mL 4.7379 mL
15 mM 0.1263 mL 0.6317 mL 1.2634 mL 3.1586 mL
20 mM 0.0948 mL 0.4738 mL 0.9476 mL 2.3689 mL
25 mM 0.0758 mL 0.3790 mL 0.7581 mL 1.8952 mL
30 mM 0.0632 mL 0.3159 mL 0.6317 mL 1.5793 mL
40 mM 0.0474 mL 0.2369 mL 0.4738 mL 1.1845 mL
50 mM 0.0379 mL 0.1895 mL 0.3790 mL 0.9476 mL
60 mM 0.0316 mL 0.1579 mL 0.3159 mL 0.7896 mL
80 mM 0.0237 mL 0.1184 mL 0.2369 mL 0.5922 mL
100 mM 0.0190 mL 0.0948 mL 0.1895 mL 0.4738 mL
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MMH2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMH2MMH 2MMH-2Molecular GluesEpigenetic Reader DomainBRD4 DegraderInhibitorinhibitorinhibit

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