2. Neuronal Signaling NF-κB Immunology/Inflammation Apoptosis GPCR/G Protein MAPK/ERK Pathway
  3. Cholinesterase (ChE) NF-κB Interleukin Related TNF Receptor CCR NOD-like Receptor (NLR) JNK NO Synthase
  4. MR2938

MR2938 is a potent AChE inhibitor, with an IC50 of 5.04 μM. MR2938 also suppresses NO production obviously (IC50 = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research.

For research use only. We do not sell to patients.

MR2938 Chemical Structure

MR2938 Chemical Structure

CAS No. : 1044870-65-6

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MR2938 Related Antibodies

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

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NLRP3 NLRP1 NOD1 NOD2

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nNOS iNOS eNOS

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Description

MR2938 is a potent AChE inhibitor, with an IC50 of 5.04 μM. MR2938 also suppresses NO production obviously (IC50 = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research[1].

IC50 & Target

AChE

5.04 ± 0.7 μM (IC50)

BChE

>20 μM (IC50)

NF-κB

 

IL-1β

 

IL-6

 

NLRP3

 

JNK

 

In Vitro

MR2938 (0-10 μM, 24 h) decreases the mRNA levels of pro-inflammatory cytokines IL-1β, TNF-α, IL-6 and CCL2 at 1.25 μM[1].
MR2938 (10 μM, 24 h) blocks NF-κB signaling pathway in LPS-induced BV-2 cells[1].
MR2938 (20 μM) shows inhibitory activities against AChE and BChE, with inhibitory rates of 91.8 ± 2.68% and 38.7 ± 11.7%, respectively[1].
MR2938 (0-10 μM) has little effect on cell viability on BV2 cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MR2938 Related Antibodies

RT-PCR[1]

Cell Line: BV-2 cells
Concentration: 0, 1.25, 2.5, 5, and 10 μM
Incubation Time: 24 h
Result: Dramatically and dose dependently reduced the mRNA levels of inflammatory factors stimulated by LPS (1 μg/mL). Compared with TNF-α, the inhibitory effect of MR2938 on IL-1β, IL-6 and CCL2 was much potent.

Western Blot Analysis[1]

Cell Line: BV-2 cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Suppressed the expression level of p65 protein, and reduced the p-p65 level. Reduced NLRP3 expression obviously. Reduced the phosphorylation level of JNK induced by LPS stimulation, while the level of JNK protein was hardly changed.
Molecular Weight

380.44

Formula

C21H24N4O3
CAS No.
SMILES

COC1=CC(OC)=C2C(NC(C3=CC=C(C=C3)N4CCN(CC4)C)=NC2=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MR2938 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MR29381044870-65-6MR 2938MR-2938Cholinesterase (ChE)NF-κBInterleukin RelatedTNF ReceptorCCRNOD-like Receptor (NLR)JNKNO SynthaseNuclear factor-κBNuclear factor-kappaBILTumor Necrosis Factor ReceptorTNFRCC chemokine receptorc-Jun N-terminal kinaseNitric oxide synthasesNOSQuinazolin-4(3H)-oneAcetylcholinesteraseButyrylcholinesteraseanti-inflammatory activityMultifunctional inhibitorAlzheimer’s diseaseInhibitorinhibitorinhibit

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