2. PROTAC Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. PROTACs EGFR
  4. MS9427 TFA

MS9427 TFA is a potent PROTAC EGFR degrader with Kds of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 TFA selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 TFA potently inhibits the proliferation of NSCLC cells. MS9427 TFA can be used for researching anticancer.

For research use only. We do not sell to patients.

MS9427 TFA Chemical Structure

MS9427 TFA Chemical Structure

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1 mg USD 160 In-stock
5 mg USD 480 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2600 In-stock
100 mg USD 4000 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of MS9427 TFA:

MS9427 TFA Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

  • Purity & Documentation

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Description

MS9427 TFA is a potent PROTAC EGFR degrader with Kds of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 TFA selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 TFA potently inhibits the proliferation of NSCLC cells. MS9427 TFA can be used for researching anticancer[1].

In Vitro

MS9427 TFA has antiproliferative activity against HCC-827 cells, with a GI50 of 0.87 ± 0.27 μM[1].
MS9427 TFA (0-10 μM, 16 h) potently induces EGFRDel19 degradation (DC50=82 ± 73 nM) and inhibits EGFR phosphorylation (p-EGFR) in a concentration-dependent manner in HCC-827 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MS9427 TFA Related Antibodies

Western Blot Analysis[1]

Cell Line: HCC-827 cells
Concentration: 1, 10, 50, 100, 200, 500, 100, and 10000 nM
Incubation Time: 16 h
Result: Inhibited EGFR phosphorylation (p-EGFR) in a concentration-dependent manner in HCC-827 cells.

Western Blot Analysis[1]

Cell Line: HCC-827 cells
Concentration: 100 nM
Incubation Time: 1, 2, 4, 6, 12, 24, 48 h
Result: Induced EGFR degradation in a time-dependent manner and through the UPS and autophagy/lysosome system.
Molecular Weight

1107.50

Formula

C50H59ClF4N8O14
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(NCCOCCOCCOCCOCCOCCC(N4CCN(CCCOC5=CC6=C(NC7=CC=C(F)C(Cl)=C7)N=CN=C6C=C5OC)CC4)=O)=C3)=O.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (135.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9029 mL 4.5147 mL 9.0293 mL
5 mM 0.1806 mL 0.9029 mL 1.8059 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9029 mL 4.5147 mL 9.0293 mL 22.5734 mL
5 mM 0.1806 mL 0.9029 mL 1.8059 mL 4.5147 mL
10 mM 0.0903 mL 0.4515 mL 0.9029 mL 2.2573 mL
15 mM 0.0602 mL 0.3010 mL 0.6020 mL 1.5049 mL
20 mM 0.0451 mL 0.2257 mL 0.4515 mL 1.1287 mL
25 mM 0.0361 mL 0.1806 mL 0.3612 mL 0.9029 mL
30 mM 0.0301 mL 0.1505 mL 0.3010 mL 0.7524 mL
40 mM 0.0226 mL 0.1129 mL 0.2257 mL 0.5643 mL
50 mM 0.0181 mL 0.0903 mL 0.1806 mL 0.4515 mL
60 mM 0.0150 mL 0.0752 mL 0.1505 mL 0.3762 mL
80 mM 0.0113 mL 0.0564 mL 0.1129 mL 0.2822 mL
100 mM 0.0090 mL 0.0451 mL 0.0903 mL 0.2257 mL
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MS9427 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS9427MS 9427MS-9427PROTACsEGFREpidermal growth factor receptorErbB-1HER1anticancerantiproliferativeNSCLCUPSautophagy/lysosome pathwayInhibitorinhibitorinhibit

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