Myoferlin inhibitor 1

Cat. No.: HY-143657 Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Myoferlin inhibitor 1 is a novel agent against pancreatic cancer metastasis through targeting myoferlin.

For research use only. We do not sell to patients.

Myoferlin inhibitor 1 Chemical Structure

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Myoferlin inhibitor 1 is a novel agent against pancreatic cancer metastasis through targeting myoferlin.

Cellular Effect

Cell Line	Type	Value	Description	References
Capan-2	IC₅₀	2.85 μM Compound: 6y	Cytotoxicity against human Capan2 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human Capan2 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 31026162]
MCF-10A	IC₅₀	27.56 μM Compound: 6y	Cytotoxicity against human MCF10A cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human MCF10A cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 31026162]
MIA PaCa-2	IC₅₀	1.54 μM Compound: 6y	Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 31026162]
PANC-1	IC₅₀	0.11 μM Compound: 6y	Antimigratory activity against human PANC1 cells measured after 18 hrs in presence of mitomycin C using crystal violet staining by inverted microscopy-based transwell assay Antimigratory activity against human PANC1 cells measured after 18 hrs in presence of mitomycin C using crystal violet staining by inverted microscopy-based transwell assay	[PMID: 31026162]
PANC-1	IC₅₀	0.12 μM Compound: 6y	Antiinvasive activity against human PANC1 cells measured after 18 hrs in presence of mitomycin C using crystal violet staining by inverted microscopy-based matrigel coated transwell assay Antiinvasive activity against human PANC1 cells measured after 18 hrs in presence of mitomycin C using crystal violet staining by inverted microscopy-based matrigel coated transwell assay	[PMID: 31026162]
PANC-1	IC₅₀	0.84 μM Compound: 6y	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human PANC1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 31026162]

Molecular Weight

456.54

Formula

C₂₆H₂₈N₆O₂

CAS No.

2366279-99-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCCCC1=CC=CC=C1)C2=CC=CC(N3N=C(CC)N=C3C4=NC=C(OC)C=N4)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (109.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1904 mL	10.9519 mL	21.9039 mL
5 mM	0.4381 mL	2.1904 mL	4.3808 mL
10 mM	0.2190 mL	1.0952 mL	2.1904 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (248 KB) HNMR (269 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin. J Med Chem. 2019 May 23;62(10):4949-4966. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1904 mL	10.9519 mL	21.9039 mL	54.7597 mL
	5 mM	0.4381 mL	2.1904 mL	4.3808 mL	10.9519 mL
	10 mM	0.2190 mL	1.0952 mL	2.1904 mL	5.4760 mL
	15 mM	0.1460 mL	0.7301 mL	1.4603 mL	3.6506 mL
	20 mM	0.1095 mL	0.5476 mL	1.0952 mL	2.7380 mL
	25 mM	0.0876 mL	0.4381 mL	0.8762 mL	2.1904 mL
	30 mM	0.0730 mL	0.3651 mL	0.7301 mL	1.8253 mL
	40 mM	0.0548 mL	0.2738 mL	0.5476 mL	1.3690 mL
	50 mM	0.0438 mL	0.2190 mL	0.4381 mL	1.0952 mL
	60 mM	0.0365 mL	0.1825 mL	0.3651 mL	0.9127 mL
	80 mM	0.0274 mL	0.1369 mL	0.2738 mL	0.6845 mL
	100 mM	0.0219 mL	0.1095 mL	0.2190 mL	0.5476 mL