2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Mitochondrial Metabolism Antibiotic
  4. Myxothiazol

Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml.

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Myxothiazol Chemical Structure

Myxothiazol Chemical Structure

CAS No. : 76706-55-3

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Based on 1 publication(s) in Google Scholar

Myxothiazol Related Antibodies

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Description

Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.01 ng/mL
Compound: Myxothiazol
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
[PMID: 10096868]
HCT-15 IC50
0.03 ng/mL
Compound: Myxothiazol
Cytotoxicity against human HCT-15 cells after 72 hrs by SRB assay
Cytotoxicity against human HCT-15 cells after 72 hrs by SRB assay
[PMID: 10096868]
SK-MEL-2 IC50
9.7 ng/mL
Compound: Myxothiazol
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
[PMID: 10096868]
SK-OV-3 IC50
0.01 ng/mL
Compound: Myxothiazol
Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
[PMID: 10096868]
XF498 IC50
0.03 ng/mL
Compound: Myxothiazol
Cytotoxicity against human XF498 cells after 72 hrs by SRB assay
Cytotoxicity against human XF498 cells after 72 hrs by SRB assay
[PMID: 10096868]
In Vitro

Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[2].
Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Myxothiazol Related Antibodies
In Vivo

Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/J6 mice[3]
Dosage: 0.56 mg/kg
Administration: I.p.; 24 hours intervals for at most 4 times
Result: A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found.
Molecular Weight

487.68

Formula

C25H33N3O3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](C1=NC(C2=NC(/C=C/[C@H](OC)[C@@H](C)/C(OC)=C\C(N)=O)=CS2)=CS1)/C=C/C=C/C(C)C
Structure Classification
Initial Source

Myxococcus fulvus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

Chloroform : 10 mg/mL (20.51 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0505 mL 10.2526 mL 20.5052 mL
5 mM 0.4101 mL 2.0505 mL 4.1010 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.53%

SDS (420 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Chloroform 1 mM 2.0505 mL 10.2526 mL 20.5052 mL 51.2631 mL
5 mM 0.4101 mL 2.0505 mL 4.1010 mL 10.2526 mL
10 mM 0.2051 mL 1.0253 mL 2.0505 mL 5.1263 mL
15 mM 0.1367 mL 0.6835 mL 1.3670 mL 3.4175 mL
20 mM 0.1025 mL 0.5126 mL 1.0253 mL 2.5632 mL
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Myxothiazol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Myxothiazol76706-55-3FungalMitochondrial MetabolismAntibioticfungimitochondrialelectrontransportchainrespiratorytoxicityInhibitorinhibitorinhibit

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