N-(4-Aminobenzoyl)-L-glutamic acid-d₄

Cat. No.: HY-W011713S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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N-(4-Aminobenzoyl)-L-glutamic acid-d₄ is the deuterium labeled 4-Nitrobenzoic acid[1].

For research use only. We do not sell to patients.

N-(4-Aminobenzoyl)-L-glutamic acid-d<sub>4</sub> Chemical Structure

N-(4-Aminobenzoyl)-L-glutamic acid-d₄ Chemical Structure

CAS No. : 461426-34-6

Size	Price	Stock	Quantity
1 mg	USD 310	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of N-(4-Aminobenzoyl)-L-glutamic acid-d₄:

(4-Aminobenzoyl)-L-glutamic acid Get quote

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Description

N-(4-Aminobenzoyl)-L-glutamic acid-d₄ is the deuterium labeled 4-Nitrobenzoic acid[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[75].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

270.27

Formula

C₁₂H₁₀D₄N₂O₅

CAS No.

461426-34-6

Unlabeled CAS

4271-30-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC[C@@H](C(O)=O)NC(C1=C([2H])C([2H])=C(N)C([2H])=C1[2H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (370.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7000 mL	18.5000 mL	37.0000 mL
5 mM	0.7400 mL	3.7000 mL	7.4000 mL
10 mM	0.3700 mL	1.8500 mL	3.7000 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (248 KB) HNMR (290 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7000 mL	18.5000 mL	37.0000 mL	92.5001 mL
	5 mM	0.7400 mL	3.7000 mL	7.4000 mL	18.5000 mL
	10 mM	0.3700 mL	1.8500 mL	3.7000 mL	9.2500 mL
	15 mM	0.2467 mL	1.2333 mL	2.4667 mL	6.1667 mL
	20 mM	0.1850 mL	0.9250 mL	1.8500 mL	4.6250 mL
	25 mM	0.1480 mL	0.7400 mL	1.4800 mL	3.7000 mL
	30 mM	0.1233 mL	0.6167 mL	1.2333 mL	3.0833 mL
	40 mM	0.0925 mL	0.4625 mL	0.9250 mL	2.3125 mL
	50 mM	0.0740 mL	0.3700 mL	0.7400 mL	1.8500 mL
	60 mM	0.0617 mL	0.3083 mL	0.6167 mL	1.5417 mL
	80 mM	0.0463 mL	0.2313 mL	0.4625 mL	1.1563 mL
	100 mM	0.0370 mL	0.1850 mL	0.3700 mL	0.9250 mL