2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. N-Ac-γ-Calicheamicin-AcBut-NHS ester

N-Ac-γ-Calicheamicin-AcBut-NHS ester 

Cat. No.: HY-103688 Purity: 95.62%
SDS COA Handling Instructions Technical Support

AcBut-N-Ac-γ-Calicheamicin is an ADC cytotoxic payload that induces cell cycle arrest and apoptosis by causing DNA double-strand breaks. AcBut-N-Ac-γ-Calicheamicin is primarily used in the synthesis of antibody-drug conjugates (ADC) and holds promise for research in the field of cancer, including acute lymphoblastic leukemia (ALL) and other hematological malignancies.

For research use only. We do not sell to patients.

N-Ac-γ-Calicheamicin-AcBut-NHS ester Chemical Structure

N-Ac-γ-Calicheamicin-AcBut-NHS ester Chemical Structure

CAS No. : 174885-02-0

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Customer Review

Based on 1 publication(s) in Google Scholar

N-Ac-γ-Calicheamicin-AcBut-NHS ester Related Antibodies

Top Publications Citing Use of Products

View All ADC Cytotoxin Isoform Specific Products:

View All Isoforms
Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

AcBut-N-Ac-γ-Calicheamicin is an ADC cytotoxic payload that induces cell cycle arrest and apoptosis by causing DNA double-strand breaks. AcBut-N-Ac-γ-Calicheamicin is primarily used in the synthesis of antibody-drug conjugates (ADC) and holds promise for research in the field of cancer, including acute lymphoblastic leukemia (ALL) and other hematological malignancies[1].

Molecular Weight

1779.73

Formula

C77H99IN6O28S3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@](CC1=O)(C#C/C=C\C#C2)/C(C([C@H]2O[C@@](O[C@H](C)[C@@H](NO[C@H](O[C@H](C)[C@H]3SC(C(C(C)=C(I)C(O[C@H](O[C@@H](C)[C@H](O)[C@H]4OC)[C@@H]4O)=C5OC)=C5OC)=O)C[C@@H]3O)[C@@H]6O)([H])[C@@H]6O[C@@](OC[C@@H]7N(CC)C(C)=O)([H])C[C@@H]7OC)=C1NC(OC)=O)=C/CSSC(C)(C)CC(N/N=C(C8=CC=C(OCCCC(ON(C9=O)C(CC9)=O)=O)C=C8)\C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (28.09 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5619 mL 2.8094 mL 5.6188 mL
5 mM 0.1124 mL 0.5619 mL 1.1238 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5619 mL 2.8094 mL 5.6188 mL 14.0471 mL
5 mM 0.1124 mL 0.5619 mL 1.1238 mL 2.8094 mL
10 mM 0.0562 mL 0.2809 mL 0.5619 mL 1.4047 mL
15 mM 0.0375 mL 0.1873 mL 0.3746 mL 0.9365 mL
20 mM 0.0281 mL 0.1405 mL 0.2809 mL 0.7024 mL
25 mM 0.0225 mL 0.1124 mL 0.2248 mL 0.5619 mL
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N-Ac-γ-Calicheamicin-AcBut-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Ac-γ-Calicheamicin-AcBut-NHS ester174885-02-0ADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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