N-Desethyl amodiaquine-d₅

Name: N-Desethyl amodiaquine-d 5
Brand: MedChemExpress
SKU: HY-128554S
Rating: 4.5 (1 reviews)

Cat. No.: HY-128554S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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N-Desethyl amodiaquine-d₅ is the deuterium labeled N-Desethyl amodiaquine. N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

For research use only. We do not sell to patients.

N-Desethyl amodiaquine-d<sub>5</sub> Chemical Structure

N-Desethyl amodiaquine-d₅ Chemical Structure

CAS No. : 1173023-19-2

Size	Price	Stock	Quantity
1 mg	USD 790	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of N-Desethyl amodiaquine-d₅:

N-Desethyl amodiaquine Get quote
N-Desethyl amodiaquine dihydrochloride Get quote
N-Desethyl amodiaquine-d₅ dihydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

332.84

Formula

C₁₈H₁₃D₅ClN₃O

CAS No.

1173023-19-2

Unlabeled CAS

79352-78-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC(C=C1)=CC2=C1C(NC3=CC(CNC([2H])([2H])C([2H])([2H])[2H])=C(C=C3)O)=CC=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (300.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0044 mL	15.0222 mL	30.0445 mL
5 mM	0.6009 mL	3.0044 mL	6.0089 mL
10 mM	0.3004 mL	1.5022 mL	3.0044 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (271 KB) SDS (420 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	3.0044 mL	15.0222 mL	30.0445 mL	75.1112 mL
	5 mM	0.6009 mL	3.0044 mL	6.0089 mL	15.0222 mL
	10 mM	0.3004 mL	1.5022 mL	3.0044 mL	7.5111 mL
	15 mM	0.2003 mL	1.0015 mL	2.0030 mL	5.0074 mL
	20 mM	0.1502 mL	0.7511 mL	1.5022 mL	3.7556 mL
	25 mM	0.1202 mL	0.6009 mL	1.2018 mL	3.0044 mL
	30 mM	0.1001 mL	0.5007 mL	1.0015 mL	2.5037 mL
	40 mM	0.0751 mL	0.3756 mL	0.7511 mL	1.8778 mL
	50 mM	0.0601 mL	0.3004 mL	0.6009 mL	1.5022 mL
	60 mM	0.0501 mL	0.2504 mL	0.5007 mL	1.2519 mL
	80 mM	0.0376 mL	0.1878 mL	0.3756 mL	0.9389 mL
	100 mM	0.0300 mL	0.1502 mL	0.3004 mL	0.7511 mL