N-Methylflindersine

Name: N-Methylflindersine
Brand: MedChemExpress
SKU: HY-N3184
Rating: 4.5 (1 reviews)

Cat. No.: HY-N3184 Purity: 98.39%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

N-Methylflindersine is a compound isolated as insect antifeedants from the East African Rutaceous medicinal plants Fagara chalybea and F. holtziana.

For research use only. We do not sell to patients.

N-Methylflindersine Chemical Structure

CAS No. : 50333-13-6

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

N-Methylflindersine is a compound isolated as insect antifeedants from the East African Rutaceous medicinal plants Fagara chalybea and F. holtziana^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Neutrophil	IC₅₀	4.28 μM Compound: 7	Antiinflammatory activity in human neutrophils assessed as fMLP-induced superoxide release after 5 mins by spectrometry Antiinflammatory activity in human neutrophils assessed as fMLP-induced superoxide release after 5 mins by spectrometry	[PMID: 17822293]

Molecular Weight

241.29

Formula

C₁₅H₁₅NO₂

CAS No.

50333-13-6

Appearance

Solid

Color

White to off-white

SMILES

CN1C2=C(C=CC=C2)C3=C(C=CC(C)(C)O3)C1=O

Structure Classification

Alkaloids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (207.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1444 mL	20.7220 mL	41.4439 mL
5 mM	0.8289 mL	4.1444 mL	8.2888 mL
10 mM	0.4144 mL	2.0722 mL	4.1444 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (5.18 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (5.18 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.39%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (254 KB) HNMR (198 KB) RP-HPLC (259 KB)

Handling Instructions (2659 KB)

References

[1]. Makoto TANIGUCHI, et al. Biocidal Alkaloids from African Fagara Plants: Inhibition of Mitochondrial Function.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1444 mL	20.7220 mL	41.4439 mL	103.6098 mL
	5 mM	0.8289 mL	4.1444 mL	8.2888 mL	20.7220 mL
	10 mM	0.4144 mL	2.0722 mL	4.1444 mL	10.3610 mL
	15 mM	0.2763 mL	1.3815 mL	2.7629 mL	6.9073 mL
	20 mM	0.2072 mL	1.0361 mL	2.0722 mL	5.1805 mL
	25 mM	0.1658 mL	0.8289 mL	1.6578 mL	4.1444 mL
	30 mM	0.1381 mL	0.6907 mL	1.3815 mL	3.4537 mL
	40 mM	0.1036 mL	0.5180 mL	1.0361 mL	2.5902 mL
	50 mM	0.0829 mL	0.4144 mL	0.8289 mL	2.0722 mL
	60 mM	0.0691 mL	0.3454 mL	0.6907 mL	1.7268 mL
	80 mM	0.0518 mL	0.2590 mL	0.5180 mL	1.2951 mL
	100 mM	0.0414 mL	0.2072 mL	0.4144 mL	1.0361 mL