N-Methylphenethylamine

Cat. No.: HY-30170 Purity: 98.53%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

N-Methylphenethylamine is a naturally occurring secondary amine neuromodulator and can be detected in human urine or plants.

For research use only. We do not sell to patients.

N-Methylphenethylamine Chemical Structure

CAS No. : 589-08-2

Size	Price	Stock	Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Liquid
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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Biological Activity
Purity & Documentation
References
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Description

N-Methylphenethylamine is a naturally occurring secondary amine neuromodulator and can be detected in human urine or plants^[1].

IC₅₀ & Target

IC50: Neuromodulator^[1]

Molecular Weight

135.21

Formula

C₉H₁₃N

CAS No.

589-08-2

Appearance

Liquid (Density: 0.93 g/cm³)

Color

Colorless to light yellow

SMILES

CNCCC1=CC=CC=C1

Structure Classification

Others

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (739.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.3959 mL	36.9795 mL	73.9590 mL
5 mM	1.4792 mL	7.3959 mL	14.7918 mL
10 mM	0.7396 mL	3.6980 mL	7.3959 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (18.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (18.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (18.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.53%

Select Batch:

Data Sheet (270 KB) SDS (614 KB)

COA (244 KB) HNMR (224 KB) LCMS (260 KB)

Handling Instructions (2659 KB)

References

[1]. P Marquardt, et al. N-Methylphenethylamine, an indirect sympathicomimetic agent in vegetables (author's transl). Arzneimittelforschung. 1976;26(11):2001-3. [Content Brief]

[2]. G B Neurath, et al.Primary and secondary amines in the human environment. Food Cosmet Toxicol. 1977 Aug;15(4):275-82. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.3959 mL	36.9795 mL	73.9590 mL	184.8976 mL
	5 mM	1.4792 mL	7.3959 mL	14.7918 mL	36.9795 mL
	10 mM	0.7396 mL	3.6980 mL	7.3959 mL	18.4898 mL
	15 mM	0.4931 mL	2.4653 mL	4.9306 mL	12.3265 mL
	20 mM	0.3698 mL	1.8490 mL	3.6980 mL	9.2449 mL
	25 mM	0.2958 mL	1.4792 mL	2.9584 mL	7.3959 mL
	30 mM	0.2465 mL	1.2327 mL	2.4653 mL	6.1633 mL
	40 mM	0.1849 mL	0.9245 mL	1.8490 mL	4.6224 mL
	50 mM	0.1479 mL	0.7396 mL	1.4792 mL	3.6980 mL
	60 mM	0.1233 mL	0.6163 mL	1.2327 mL	3.0816 mL
	80 mM	0.0924 mL	0.4622 mL	0.9245 mL	2.3112 mL
	100 mM	0.0740 mL	0.3698 mL	0.7396 mL	1.8490 mL