2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. N-Nonyldeoxynojirimycin

N-Nonyldeoxynojirimycin  (Synonyms: NN-DNJ; Nonyl-DNJ)

Cat. No.: HY-107532 Purity: ≥98.0%
SDS COA Handling Instructions

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N-Nonyldeoxynojirimycin (NN-DNJ) is a potent inhibitor of alpha-glucosidase and alpha-1,6-glucosidase (IC50s, 0.42, 8.4 μM, respectively), inhibits glycogen breakdown.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

N-Nonyldeoxynojirimycin Chemical Structure

N-Nonyldeoxynojirimycin Chemical Structure

CAS No. : 81117-35-3

Size Price Stock Quantity
5 mg USD 170 In-stock
10 mg USD 270 In-stock
25 mg USD 540 In-stock
50 mg USD 860 In-stock
100 mg USD 1380 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

N-Nonyldeoxynojirimycin Related Antibodies

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  • Purity & Documentation

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Description

N-Nonyldeoxynojirimycin (NN-DNJ) is a potent inhibitor of alpha-glucosidase and alpha-1,6-glucosidase (IC50s, 0.42, 8.4 μM, respectively), inhibits glycogen breakdown[1].

IC50 & Target

IC50: 0.42 μM (alpha-glucosidase), 8.4 μM (alpha-1,6-glucosidase)[1]
Cellular Effect
Cell Line Type Value Description References
RAW IC50
4 μM
Compound: 9
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay
[PMID: 24900289]
SH-SY5Y IC50
0.003 μM
Compound: 2; D-NNDNJ
Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay
Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay
[PMID: 31075609]
SH-SY5Y IC50
5.6 μM
Compound: 2; D-NNDNJ
Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay
Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay
[PMID: 31075609]
Vero CC50
> 40 μM
Compound: NNDNJ
Cytotoxicity against african green monkey Vero cells by MTT assay
Cytotoxicity against african green monkey Vero cells by MTT assay
[PMID: 19223639]
Vero EC50
1.1 μM
Compound: NNDNJ
Antiviral activity against Dengue virus C infected in african green monkey Vero cells assessed as reduction in viral titer after 72 hrs by plaque reduction assay
Antiviral activity against Dengue virus C infected in african green monkey Vero cells assessed as reduction in viral titer after 72 hrs by plaque reduction assay
[PMID: 19223639]
Molecular Weight

289.41

Formula

C15H31NO4
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (172.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4553 mL 17.2765 mL 34.5531 mL
5 mM 0.6911 mL 3.4553 mL 6.9106 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (393 KB)

COA (244 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4553 mL 17.2765 mL 34.5531 mL 86.3826 mL
5 mM 0.6911 mL 3.4553 mL 6.9106 mL 17.2765 mL
10 mM 0.3455 mL 1.7277 mL 3.4553 mL 8.6383 mL
15 mM 0.2304 mL 1.1518 mL 2.3035 mL 5.7588 mL
20 mM 0.1728 mL 0.8638 mL 1.7277 mL 4.3191 mL
25 mM 0.1382 mL 0.6911 mL 1.3821 mL 3.4553 mL
30 mM 0.1152 mL 0.5759 mL 1.1518 mL 2.8794 mL
40 mM 0.0864 mL 0.4319 mL 0.8638 mL 2.1596 mL
50 mM 0.0691 mL 0.3455 mL 0.6911 mL 1.7277 mL
60 mM 0.0576 mL 0.2879 mL 0.5759 mL 1.4397 mL
80 mM 0.0432 mL 0.2160 mL 0.4319 mL 1.0798 mL
100 mM 0.0346 mL 0.1728 mL 0.3455 mL 0.8638 mL
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N-Nonyldeoxynojirimycin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Nonyldeoxynojirimycin81117-35-3NN-DNJ Nonyl-DNJGlucosidaseInhibitorinhibitorinhibit

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