Naloxone methiodide

Name: Naloxone methiodide
Brand: MedChemExpress
SKU: HY-137279
Rating: 4.5 (1 reviews)

Cat. No.: HY-137279 Purity: 99.7%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Naloxone methiodide is a peripherally restricted, nonselective, and competitive opioid receptor antagonist. Naloxone methiodide does not penetrate the blood-brain barrier.

For research use only. We do not sell to patients.

Naloxone methiodide Chemical Structure

CAS No. : 93302-47-7

Size	Price	Stock	Quantity
1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All Opioid Receptor Isoform Specific Products:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

Naloxone methiodide is a peripherally restricted, nonselective, and competitive opioid receptor antagonist. Naloxone methiodide does not penetrate the blood-brain barrier^[1]^[2].

In Vivo

Naloxone‐methiodide (10 mg/mL; 200 μL; i.p.), induces abdominal hypersensitivity in IL-10^?/? mice with colitis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Ten- to twelve-week-old IL-10 gene-deficient male (IL-10−/−) mice on C57BL/6 genetic background^[2]
Dosage:	10 mg/mL; 200 μL
Administration:	Intraperitoneally
Result:	In piroxicam-treated IL-10^−/− mice induced abdominal pain.

Molecular Weight

469.31

Formula

C₂₀H₂₄INO₄

CAS No.

93302-47-7

Appearance

Solid

Color

White to off-white

SMILES

O[C@@]1(CCC2=O)[C@@]([C@@]2([H])OC3=C4O)(CC5)C3=C(C=C4)C[C@H]1[N@@+]5(C)CC=C.[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (532.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (53.27 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1308 mL	10.6539 mL	21.3079 mL
5 mM	0.4262 mL	2.1308 mL	4.2616 mL
10 mM	0.2131 mL	1.0654 mL	2.1308 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.43 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.43 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.7%

Select Batch:

Data Sheet (281 KB) SDS (393 KB)

COA (260 KB)

Handling Instructions (2659 KB)

References

[1]. Basso L, et al. TRPV1 promotes opioid analgesia during inflammation. Sci Signal. 2019;12(575):eaav0711. Published 2019 Apr 2. [Content Brief]

[2]. Basso L, et al. Endogenous control of inflammatory visceral pain by T cell-derived opioids in IL-10-deficient mice. Neurogastroenterol Motil. 2020;32(2):e13743. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.1308 mL	10.6539 mL	21.3079 mL	53.2697 mL
	5 mM	0.4262 mL	2.1308 mL	4.2616 mL	10.6539 mL
	10 mM	0.2131 mL	1.0654 mL	2.1308 mL	5.3270 mL
	15 mM	0.1421 mL	0.7103 mL	1.4205 mL	3.5513 mL
	20 mM	0.1065 mL	0.5327 mL	1.0654 mL	2.6635 mL
	25 mM	0.0852 mL	0.4262 mL	0.8523 mL	2.1308 mL
	30 mM	0.0710 mL	0.3551 mL	0.7103 mL	1.7757 mL
	40 mM	0.0533 mL	0.2663 mL	0.5327 mL	1.3317 mL
	50 mM	0.0426 mL	0.2131 mL	0.4262 mL	1.0654 mL
DMSO	60 mM	0.0355 mL	0.1776 mL	0.3551 mL	0.8878 mL
	80 mM	0.0266 mL	0.1332 mL	0.2663 mL	0.6659 mL
	100 mM	0.0213 mL	0.1065 mL	0.2131 mL	0.5327 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.