2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. Nebularine

Nebularine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

Nebularine Chemical Structure

Nebularine Chemical Structure

CAS No. : 550-33-4

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Based on 1 publication(s) in Google Scholar

Nebularine Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Nebularine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Cellular Effect
Cell Line Type Value Description References
L929 IC50
2.37 μM
Compound: 3, Nebularine
Cytotoxicity against mouse L929 cells assessed as cell viability after 72 hrs by WST-1 assay
Cytotoxicity against mouse L929 cells assessed as cell viability after 72 hrs by WST-1 assay
[PMID: 24283924]
Vero IC50
0.6 nM
Compound: Nebularine
Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay
Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay
[PMID: 10464017]
Molecular Weight

252.23

Formula

C10H12N4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@@H]1N2C=NC3=C2N=CN=C3
Structure Classification
Initial Source

Microbispora sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (495.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9646 mL 19.8232 mL 39.6464 mL
5 mM 0.7929 mL 3.9646 mL 7.9293 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9646 mL 19.8232 mL 39.6464 mL 99.1159 mL
5 mM 0.7929 mL 3.9646 mL 7.9293 mL 19.8232 mL
10 mM 0.3965 mL 1.9823 mL 3.9646 mL 9.9116 mL
15 mM 0.2643 mL 1.3215 mL 2.6431 mL 6.6077 mL
20 mM 0.1982 mL 0.9912 mL 1.9823 mL 4.9558 mL
25 mM 0.1586 mL 0.7929 mL 1.5859 mL 3.9646 mL
30 mM 0.1322 mL 0.6608 mL 1.3215 mL 3.3039 mL
40 mM 0.0991 mL 0.4956 mL 0.9912 mL 2.4779 mL
50 mM 0.0793 mL 0.3965 mL 0.7929 mL 1.9823 mL
60 mM 0.0661 mL 0.3304 mL 0.6608 mL 1.6519 mL
80 mM 0.0496 mL 0.2478 mL 0.4956 mL 1.2389 mL
100 mM 0.0396 mL 0.1982 mL 0.3965 mL 0.9912 mL
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Nebularine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nebularine550-33-4Nucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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