2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. Nebularine

Nebularine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

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Nebularine Chemical Structure

Nebularine Chemical Structure

CAS No. : 550-33-4

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Based on 1 publication(s) in Google Scholar

Nebularine Related Antibodies

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Description

Nebularine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Cellular Effect
Cell Line Type Value Description References
L929 IC50
2.37 μM
Compound: 3, Nebularine
Cytotoxicity against mouse L929 cells assessed as cell viability after 72 hrs by WST-1 assay
Cytotoxicity against mouse L929 cells assessed as cell viability after 72 hrs by WST-1 assay
[PMID: 24283924]
Vero IC50
0.6 nM
Compound: Nebularine
Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay
Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay
[PMID: 10464017]
Molecular Weight

252.23

Formula

C10H12N4O4
CAS No.
SMILES

OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@@H]1N2C=NC3=C2N=CN=C3
Structure Classification
Initial Source

Microbispora sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nebularine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nebularine550-33-4Nucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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