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  4. Neplanocin A

Neplanocin A  (Synonyms: (-)-Neplanocin A)

Cat. No.: HY-130430 Purity: ≥99.0%
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Neplanocin A ((-)-Neplanocin A) is an antitumor antibiotic with significant antitumor activity against murine L1210 leukemia. Neplanocin A is also an irreversible inhibitor of AdoHcy hydrolase (Ki=8.39 nM). Neplanocin A also has antiviral activity and is effective against vaccinia virus. Neplanocin A is obtained from Ampulariella regularis.

For research use only. We do not sell to patients.

Neplanocin A Chemical Structure

Neplanocin A Chemical Structure

CAS No. : 72877-50-0

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500 μg In-stock
1 mg In-stock
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Based on 1 publication(s) in Google Scholar

Neplanocin A Related Antibodies

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Description

Neplanocin A ((-)-Neplanocin A) is an antitumor antibiotic with significant antitumor activity against murine L1210 leukemia. Neplanocin A is also an irreversible inhibitor of AdoHcy hydrolase (Ki=8.39 nM). Neplanocin A also has antiviral activity and is effective against vaccinia virus. Neplanocin A is obtained from Ampulariella regularis[1].

IC50 & Target

AdoHcy hydrolase; vaccinia[1].
Cellular Effect
Cell Line Type Value Description References
A549 IC50
1.22 μM
Compound: 1
Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
[PMID: 26010585]
A549 IC50
2.16 μM
Compound: Neplanocin A; 1a
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by SRB assay
[PMID: 29906687]
HCT-116 IC50
0.9 μM
Compound: 1
Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
[PMID: 26010585]
HCT-116 IC50
1.45 μM
Compound: Neplanocin A; 1a
Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 72 hrs by SRB assay
Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 72 hrs by SRB assay
[PMID: 29906687]
MDA-MB-231 IC50
0.4 μM
Compound: 1
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
[PMID: 26010585]
MDA-MB-231 IC50
0.86 μM
Compound: Neplanocin A; 1a
Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 72 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 72 hrs by SRB assay
[PMID: 29906687]
PC-3 IC50
2.14 μM
Compound: Neplanocin A; 1a
Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 72 hrs by SRB assay
Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 72 hrs by SRB assay
[PMID: 29906687]
PC-3 IC50
3.7 μM
Compound: 1
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
[PMID: 26010585]
SH-SY5Y IC50
10 nM
Compound: 8, NepA
Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysis
Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysis
[PMID: 24813734]
SK-HEP1 IC50
2.36 μM
Compound: Neplanocin A; 1a
Cytotoxicity against human SKHEP1 cells assessed as decrease in cell viability after 72 hrs by SRB assay
Cytotoxicity against human SKHEP1 cells assessed as decrease in cell viability after 72 hrs by SRB assay
[PMID: 29906687]
SK-HEP1 IC50
4.5 μM
Compound: 1
Cytotoxicity against human SKHEP1 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
Cytotoxicity against human SKHEP1 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
[PMID: 26010585]
SNU-638 IC50
0.7 μM
Compound: 1
Cytotoxicity against human SNU638 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
Cytotoxicity against human SNU638 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
[PMID: 26010585]
SNU-638 IC50
0.82 μM
Compound: Neplanocin A; 1a
Cytotoxicity against human SNU638 cells assessed as decrease in cell viability after 72 hrs by SRB assay
Cytotoxicity against human SNU638 cells assessed as decrease in cell viability after 72 hrs by SRB assay
[PMID: 29906687]
Vero IC50
0.26 μg/mL
Compound: 1 (NPA)
Cytotoxic effect on host cells during growth phase of virus in vero cell cultures using MTT method
Cytotoxic effect on host cells during growth phase of virus in vero cell cultures using MTT method
10.1016/S0960-894X(01)80163-3
Vero IC50
152 μg/mL
Compound: 1 (NPA)
Cytotoxic effect on host cells during stationary phase of virus in vero cell cultures using MTT method
Cytotoxic effect on host cells during stationary phase of virus in vero cell cultures using MTT method
10.1016/S0960-894X(01)80163-3
Vero IC50
155 μg/mL
Compound: 1a (NPA)
Cytotoxic concentration required to reduce the number of Vero cells by 50%
Cytotoxic concentration required to reduce the number of Vero cells by 50%
[PMID: 8809173]
In Vitro

Neplanocin A (1 μM; 0-70 h) inhibits the growth of L929 mouse cells[1].
Neplanocin A (1 μM; 72 h) inhibits vaccinia virus plaque formation in monolayer cultures of mouse L-cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neplanocin A Related Antibodies

Cell Viability Assay[1]

Cell Line: L929 mouse cells
Concentration: 1 μM
Incubation Time: 0-70 h
Result: Slowed the rate of increase in cell number.
Molecular Weight

263.25

Formula

C11H13N5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C(N)N=CN=C23
Structure Classification
Initial Source

Ampullariella regular
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (255 KB)

Handling Instructions (2659 KB)
References
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Neplanocin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neplanocin A72877-50-0(-)-Neplanocin AAntibioticOrthopoxvirusvacciniaAmpullariella regulariscancertumorvirusleukemiaInhibitorinhibitorinhibit

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