Niacin hydrochloride (Synonyms: Nicotinic acid hydrochloride; Vitamin B3 hydrochloride)

Cat. No.: HY-B0143A: FAQs
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Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases.

For research use only. We do not sell to patients.

Niacin hydrochloride Chemical Structure

CAS No. : 636-79-3

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Other In-stock Forms of Niacin hydrochloride:

Niacin

Other Forms of Niacin hydrochloride:

Niacin In-stock

8 Publications Citing Use of MCE Niacin hydrochloride

: Niacin hydrochloride purchased from MedChemExpress. Usage Cited in: Glia. 2018 Feb;66(2):256-278. [Abstract]; Representative images and quantitative analysis showing the effects of Niacin (1 mM, 10 min) and MK-6892 (10 lM, 10 min) on Akt phosphorylation levels in primary cultured microglia.

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Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

In Vitro

Niacin hydrochloride (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism^[1].
Niacin hydrochloride (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	Cumulus cells and oocytes of prepubertal gilts
Concentration:	600 μM
Incubation Time:	42 hours
Result:	Up-regulated the relative expression of the anti-apoptotic gene BCL2 and lipid metabolism gene ACACA while down-regulated the pro-apoptotic gene BAX.

Cell Proliferation Assay^[2]

Cell Line:	Rat ascites hepatoma cell line of AH109A
Concentration:	0-40 μM
Incubation Time:	24 hours
Result:	Had no effect on the proliferation of AH109A cells but suppressed cell invasion from 2.5 μM to 40 μM.

In Vivo

Niacin hydrochloride (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 mice^[3]
Dosage:	3-300 mg/kg
Administration:	Subcutaneous injection; once
Result:	Induced vasodilation in a dose-dependent manner.

Clinical Trial

Molecular Weight

159.57

Formula

C₆H₆ClNO₂

CAS No.

636-79-3

SMILES

O=C(C1=CC=CN=C1)O.Cl

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15;169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18. [Content Brief]

[2]. Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar;69(3):653-8. [Content Brief]

[3]. Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7. [Content Brief]

Niacin hydrochloride Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Niacin636-79-3Nicotinic acidVitamin B3Vitamin B 3Vitamin B-3Endogenous MetaboliteApoptosisapoptosiscardiovascular diseasescancerInhibitorinhibitorinhibit

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