2. Membrane Transporter/Ion Channel Immunology/Inflammation
  3. Chloride Channel COX
  4. Niflumic acid (Standard)

Niflumic acid (Standard) is the analytical standard of Niflumic acid. This product is intended for research and analytical applications. Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC50 value of 100 nM. Niflumic acid induces apoptosis through caspase-8/Bid/Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis.

For research use only. We do not sell to patients.

Niflumic acid (Standard) Chemical Structure

Niflumic acid (Standard) Chemical Structure

CAS No. : 4394-00-7

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Description
Molecular Weight

282.22

Formula

C13H9F3N2O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2)O
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Niflumic acid (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Niflumic acid (Standard)4394-00-7Chloride ChannelCOXCl− Channels CyclooxygenaseNiflumic AcidChloride Channel/COX InhibitorInhibitorinhibitorinhibit

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