2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. Nimucitinib

Nimucitinib is a Janus kinase (JAK) inhibitor.

For research use only. We do not sell to patients.

Nimucitinib Chemical Structure

Nimucitinib Chemical Structure

CAS No. : 2740557-24-6

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5 mg USD 290 In-stock
10 mg USD 450 In-stock
50 mg USD 1240 In-stock
100 mg USD 1850 In-stock
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Based on 1 publication(s) in Google Scholar

Nimucitinib Related Antibodies

Top Publications Citing Use of Products

View All JAK Isoform Specific Products:

View All Isoforms
JAK1 JAK2 JAK3 Tyk2 JAK

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Description

Nimucitinib is a Janus kinase (JAK) inhibitor[1].

Molecular Weight

480.51

Formula

C25H26F2N6O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

FC1=CC(F)=CC(CNC2=CC(NC3=CC(NC([C@H]4CCCNC4)=O)=CC=C3)=NC=C2C(N)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (260.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0811 mL 10.4056 mL 20.8112 mL
5 mM 0.4162 mL 2.0811 mL 4.1622 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0811 mL 10.4056 mL 20.8112 mL 52.0281 mL
5 mM 0.4162 mL 2.0811 mL 4.1622 mL 10.4056 mL
10 mM 0.2081 mL 1.0406 mL 2.0811 mL 5.2028 mL
15 mM 0.1387 mL 0.6937 mL 1.3874 mL 3.4685 mL
20 mM 0.1041 mL 0.5203 mL 1.0406 mL 2.6014 mL
25 mM 0.0832 mL 0.4162 mL 0.8324 mL 2.0811 mL
30 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.7343 mL
40 mM 0.0520 mL 0.2601 mL 0.5203 mL 1.3007 mL
50 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0406 mL
60 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.8671 mL
80 mM 0.0260 mL 0.1301 mL 0.2601 mL 0.6504 mL
100 mM 0.0208 mL 0.1041 mL 0.2081 mL 0.5203 mL
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Nimucitinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nimucitinib2740557-24-6JAKJanus kinaseInhibitorinhibitorinhibit

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