NODAGA-LM3 TFA

Cat. No.: HY-P5362A: FAQs
Data Sheet Handling Instructions

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NODAGA-LM3 TFA can be labeled by ⁶⁸Ga for PET imaging. ⁶⁸Ga-NODAGA-LM3 TFA is a SSTR2 antagonist, and can be used for imaging of SSTR positive paragangliomas.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

NODAGA-LM3 TFA Chemical Structure

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Other Forms of NODAGA-LM3 TFA:

NODAGA-LM3 Get quote

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•Related Small Molecules:

•Related Proteins:

View All Somatostatin Receptor Isoform Specific Products:

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SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

Biological Activity
Purity & Documentation
References
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Description

NODAGA-LM3 TFA can be labeled by ⁶⁸Ga for PET imaging. ⁶⁸Ga-NODAGA-LM3 TFA is a SSTR2 antagonist, and can be used for imaging of SSTR positive paragangliomas^[1]^[2].

IC₅₀ & Target^[1]

SSTR2

Molecular Weight

1521.11 (free acid)

Formula

C₇₀H₉₁ClF₃N₁₅O₂₁S₂.xC₂HF₃O₂

Appearance

Solid

Color

White to off-white

Sequence

{NODAGA}-{p-Cl-Phe}-{d-Cys}-Tyr-{d-Phe(4-amino-carbamoyl)}-Lys-Thr-Cys-{d-Tyr}-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence Shortening

{NODAGA}-{p-Cl-Phe}-{d-Cys}-Y-{d-Phe(4-amino-carbamoyl)}-KTC-{d-Tyr}-NH2 (Disulfide bridge: Cys2-Cys7)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fani M, et al. PET of somatostatin receptor-positive tumors using 64Cu- and 68Ga-somatostatin antagonists: the chelate makes the difference. J Nucl Med. 2011 Jul;52(7):1110-8. [Content Brief]

[2]. Zhu W, et al. A Prospective, Randomized, Double-Blind Study to Evaluate the Safety, Biodistribution, and Dosimetry of 68Ga-NODAGA-LM3 and 68Ga-DOTA-LM3 in Patients with Well-Differentiated Neuroendocrine Tumors. J Nucl Med. 2021 Oct;62(10):1398-1405. [Content Brief]

NODAGA-LM3 TFA Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NODAGA-LM3Somatostatin ReceptorSSTRsSSTRparagangliomasPET68GaInhibitorinhibitorinhibit

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