Norfluoxetine hydrochloride

Cat. No.: HY-W011235 Purity: 99.58%: FAQs
Data Sheet SDS COA Handling Instructions

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Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity.

For research use only. We do not sell to patients.

Norfluoxetine hydrochloride Chemical Structure

CAS No. : 57226-68-3

Size	Price	Stock	Quantity
1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 720	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Other Forms of Norfluoxetine hydrochloride:

Norfluoxetine-d₅ hydrochloride Get quote
Norfluoxetine Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

View All Calcium Channel Isoform Specific Products:

View All Isoforms

N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

5-HT Receptor

Ca_V3.3

5 μM (IC₅₀)

In Vivo

Pretreatment with Fluoxetine or Norfluoxetine hydrochloride (20mg/kg s.c.), as well as Phenytoin (30 mg/kg s.c.) and Clonazepam (0.1mg/kg s.c.) significantly increases both the rate and duration of survival, demonstrating a significant protective effect against Pentylenetetrazol-induced epilepsy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

331.76

Formula

C₁₆H₁₇ClF₃NO

CAS No.

57226-68-3

Appearance

Solid

Color

White to off-white

SMILES

FC(F)(F)C1=CC=C(OC(C2=CC=CC=C2)CCN)C=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (376.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0142 mL	15.0711 mL	30.1423 mL
5 mM	0.6028 mL	3.0142 mL	6.0285 mL
10 mM	0.3014 mL	1.5071 mL	3.0142 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.58%

Select Batch:

Data Sheet (272 KB) SDS (701 KB)

COA (247 KB) HNMR (251 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Valéria Kecskeméti, et al. Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies. Brain Res Bull. 2005 Sep 30;67(1-2):126-32. [Content Brief]

[2]. Achraf Traboulsie, et al. T-type calcium channels are inhibited by fluoxetine and its metabolite norfluoxetine. Mol Pharmacol. 2006 Jun;69(6):1963-8. [Content Brief]

[3]. Hyeon-Cheol Jeong, et al. Prediction of Fluoxetine and Norfluoxetine Pharmacokinetic Profiles Using Physiologically Based Pharmacokinetic Modeling. Clin Pharmacol. 2021 Nov;61(11):1505-1513. [Content Brief]

[4]. D T Wong, et al. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology. 1993 Jun;8(4):337-44. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0142 mL	15.0711 mL	30.1423 mL	75.3557 mL
	5 mM	0.6028 mL	3.0142 mL	6.0285 mL	15.0711 mL
	10 mM	0.3014 mL	1.5071 mL	3.0142 mL	7.5356 mL
	15 mM	0.2009 mL	1.0047 mL	2.0095 mL	5.0237 mL
	20 mM	0.1507 mL	0.7536 mL	1.5071 mL	3.7678 mL
	25 mM	0.1206 mL	0.6028 mL	1.2057 mL	3.0142 mL
	30 mM	0.1005 mL	0.5024 mL	1.0047 mL	2.5119 mL
	40 mM	0.0754 mL	0.3768 mL	0.7536 mL	1.8839 mL
	50 mM	0.0603 mL	0.3014 mL	0.6028 mL	1.5071 mL
	60 mM	0.0502 mL	0.2512 mL	0.5024 mL	1.2559 mL
	80 mM	0.0377 mL	0.1884 mL	0.3768 mL	0.9419 mL
	100 mM	0.0301 mL	0.1507 mL	0.3014 mL	0.7536 mL