2. Metabolic Enzyme/Protease Anti-infection
  3. Phosphodiesterase (PDE) Parasite
  4. NPD-001

NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM.

For research use only. We do not sell to patients.

NPD-001 Chemical Structure

NPD-001 Chemical Structure

CAS No. : 469863-16-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 888 In-stock
Solution
10 mM * 1 mL in DMSO USD 888 In-stock
Solid
5 mg USD 690 In-stock
10 mg USD 1150 In-stock
25 mg USD 2300 In-stock
50 mg USD 3650 In-stock
100 mg USD 5900 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

NPD-001 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

View All Parasite Isoform Specific Products:

View All Isoforms
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM[1].

IC50 & Target

Trypanosoma

 

Molecular Weight

584.72

Formula

C33H40N6O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2CCCCCC2)N=C(C3=CC=C(OC)C(OCCCCOC4=CC=C(C5=NN=NN5)C=C4)=C3)[C@@]6([H])CC=CC[C@@]16[H].[Relative stereochemistry]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (171.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7102 mL 8.5511 mL 17.1022 mL
5 mM 0.3420 mL 1.7102 mL 3.4204 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7102 mL 8.5511 mL 17.1022 mL 42.7555 mL
5 mM 0.3420 mL 1.7102 mL 3.4204 mL 8.5511 mL
10 mM 0.1710 mL 0.8551 mL 1.7102 mL 4.2756 mL
15 mM 0.1140 mL 0.5701 mL 1.1401 mL 2.8504 mL
20 mM 0.0855 mL 0.4276 mL 0.8551 mL 2.1378 mL
25 mM 0.0684 mL 0.3420 mL 0.6841 mL 1.7102 mL
30 mM 0.0570 mL 0.2850 mL 0.5701 mL 1.4252 mL
40 mM 0.0428 mL 0.2138 mL 0.4276 mL 1.0689 mL
50 mM 0.0342 mL 0.1710 mL 0.3420 mL 0.8551 mL
60 mM 0.0285 mL 0.1425 mL 0.2850 mL 0.7126 mL
80 mM 0.0214 mL 0.1069 mL 0.2138 mL 0.5344 mL
100 mM 0.0171 mL 0.0855 mL 0.1710 mL 0.4276 mL
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NPD-001 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NPD-001469863-16-9NPD001NPD 001Phosphodiesterase (PDE)ParasiteTrypanosoma bruceihuman African trypanosomiasisHATpyridazinonephosphodiesterasephenylpyridazinoneparasiteInhibitorinhibitorinhibit

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