2. Apoptosis
  3. MDM-2/p53
  4. NSC405640

NSC405640 is a potent inhibitor of the MDM2-p53 interaction. NSC405640 rescues structural p53 mutations. NSC405640 selectively inhibits the growth of cell lines with wild-type p53.

For research use only. We do not sell to patients.

NSC405640 Chemical Structure

NSC405640 Chemical Structure

CAS No. : 1135-99-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
25 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

NSC405640 is a potent inhibitor of the MDM2-p53 interaction. NSC405640 rescues structural p53 mutations. NSC405640 selectively inhibits the growth of cell lines with wild-type p53[1].

Molecular Weight

343.82

Formula

C12H10Cl2Sn
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

Cl[Sn](C1=CC=CC=C1)(C2=CC=CC=C2)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (101.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9085 mL 14.5425 mL 29.0850 mL
5 mM 0.5817 mL 2.9085 mL 5.8170 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9085 mL 14.5425 mL 29.0850 mL 72.7125 mL
5 mM 0.5817 mL 2.9085 mL 5.8170 mL 14.5425 mL
10 mM 0.2908 mL 1.4542 mL 2.9085 mL 7.2712 mL
15 mM 0.1939 mL 0.9695 mL 1.9390 mL 4.8475 mL
20 mM 0.1454 mL 0.7271 mL 1.4542 mL 3.6356 mL
25 mM 0.1163 mL 0.5817 mL 1.1634 mL 2.9085 mL
30 mM 0.0969 mL 0.4847 mL 0.9695 mL 2.4237 mL
40 mM 0.0727 mL 0.3636 mL 0.7271 mL 1.8178 mL
50 mM 0.0582 mL 0.2908 mL 0.5817 mL 1.4542 mL
60 mM 0.0485 mL 0.2424 mL 0.4847 mL 1.2119 mL
80 mM 0.0364 mL 0.1818 mL 0.3636 mL 0.9089 mL
100 mM 0.0291 mL 0.1454 mL 0.2908 mL 0.7271 mL
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NSC405640 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC4056401135-99-5NSC 405640NSC-405640MDM-2/p53p53interactionselectiveInhibitorinhibitorinhibit

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