Obidoxime dichloride

Cat. No.: HY-W011108 Purity: 96.60%: FAQs
Data Sheet SDS COA Handling Instructions

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Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated.

For research use only. We do not sell to patients.

Obidoxime dichloride Chemical Structure

CAS No. : 114-90-9

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Biological Activity
Purity & Documentation
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Description

In Vivo

Obidoxime dichloride (intramuscular injection; 10 mg/kg; after 60 mins) exhibits a LD₅₀ of 57.7 mg/kg after administration of sarin, and it reduces reduces acute toxicity of sarin was evaluated^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NMRI male mice
Dosage:	10 mg/kg
Administration:	Intramuscular injection
Result:	Was effective in reactivating sarin-inhibited acetylcholinesterase (AChE).

Molecular Weight

359.21

Formula

C₁₄H₁₆Cl₂N₄O₃

CAS No.

114-90-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

O/N=C/C1=CC=[N+](C=C1)COC[N+]2=CC=C(C=C2)/C=N/O.[Cl-].[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation

Purity: 96.60%

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Data Sheet (264 KB) SDS (252 KB)

COA (244 KB)

Handling Instructions (2659 KB)

References

[1]. Kassa J,et al. A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.Toxicol Mech Methods. 2015 Mar;25(3):229-33. [Content Brief]