1. Neuronal Signaling
  2. Cholinesterase (ChE)
  3. Obidoxime dichloride

Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated.

For research use only. We do not sell to patients.

Obidoxime dichloride Chemical Structure

Obidoxime dichloride Chemical Structure

CAS No. : 114-90-9

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Description

Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated[1].

In Vivo

Obidoxime dichloride (intramuscular injection; 10 mg/kg; after 60 mins) exhibits a LD50 of 57.7 mg/kg after administration of sarin, and it reduces reduces acute toxicity of sarin was evaluated[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NMRI male mice
Dosage: 10 mg/kg
Administration: Intramuscular injection
Result: Was effective in reactivating sarin-inhibited acetylcholinesterase (AChE).
Molecular Weight

359.21

Formula

C14H16Cl2N4O3

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O/N=C/C1=CC=[N+](C=C1)COC[N+]2=CC=C(C=C2)/C=N/O.[Cl-].[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (278.39 mM; Need ultrasonic)

DMSO : 1 mg/mL (2.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7839 mL 13.9194 mL 27.8389 mL
5 mM 0.5568 mL 2.7839 mL 5.5678 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 96.60%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.7839 mL 13.9194 mL 27.8389 mL 69.5972 mL
H2O 5 mM 0.5568 mL 2.7839 mL 5.5678 mL 13.9194 mL
10 mM 0.2784 mL 1.3919 mL 2.7839 mL 6.9597 mL
15 mM 0.1856 mL 0.9280 mL 1.8559 mL 4.6398 mL
20 mM 0.1392 mL 0.6960 mL 1.3919 mL 3.4799 mL
25 mM 0.1114 mL 0.5568 mL 1.1136 mL 2.7839 mL
30 mM 0.0928 mL 0.4640 mL 0.9280 mL 2.3199 mL
40 mM 0.0696 mL 0.3480 mL 0.6960 mL 1.7399 mL
50 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3919 mL
60 mM 0.0464 mL 0.2320 mL 0.4640 mL 1.1600 mL
80 mM 0.0348 mL 0.1740 mL 0.3480 mL 0.8700 mL
100 mM 0.0278 mL 0.1392 mL 0.2784 mL 0.6960 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Obidoxime dichloride
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HY-W011108
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