2. Anti-infection
  3. Bacterial
  4. Olanexidine hydrochloride

Olanexidine hydrochloride is a monobiguanide compound with bactericidal activity. Olanexidine probably binds to the cell membrane, destroys membrane integrity. Olanexidine hydrochloride is active against a wide range of bacteria, including Gram-positive and Gram-negative bacteria. Olanexidine exhibits the bactericidal concentration of 109 μg/mL for Gram-positive bacilli.

For research use only. We do not sell to patients.

Olanexidine hydrochloride Chemical Structure

Olanexidine hydrochloride Chemical Structure

CAS No. : 146509-94-6

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1 mg USD 56 In-stock
5 mg USD 170 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Olanexidine hydrochloride:

Olanexidine hydrochloride Related Antibodies

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  • Purity & Documentation

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Description

Olanexidine hydrochloride is a monobiguanide compound with bactericidal activity. Olanexidine probably binds to the cell membrane, destroys membrane integrity. Olanexidine hydrochloride is active against a wide range of bacteria, including Gram-positive and Gram-negative bacteria. Olanexidine exhibits the bactericidal concentration of 109 μg/mL for Gram-positive bacilli[1].

In Vitro

Olanexidine shows a bactericidal mechanism of (i) interacts with the bacterial surface molecules, such as lipopolysaccharide and lipoteichoic acid, (ii) disrupts the cell membranes of liposomes, which are artificial bacterial membrane models, (iii) enhances the membrane permeability of Escherichia coli, (iv) disrupts the membrane integrity of S. aureus, and (v) denatures proteins at relatively high concentrations (≥160 μg/ml)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Olanexidine hydrochloride Related Antibodies
Molecular Weight

408.80

Formula

C17H28Cl3N5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N=C(NC(NCCCCCCCC)=N)NCC1=CC=C(C(Cl)=C1)Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (152.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4462 mL 12.2309 mL 24.4618 mL
5 mM 0.4892 mL 2.4462 mL 4.8924 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (5.09 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4462 mL 12.2309 mL 24.4618 mL 61.1546 mL
5 mM 0.4892 mL 2.4462 mL 4.8924 mL 12.2309 mL
10 mM 0.2446 mL 1.2231 mL 2.4462 mL 6.1155 mL
15 mM 0.1631 mL 0.8154 mL 1.6308 mL 4.0770 mL
20 mM 0.1223 mL 0.6115 mL 1.2231 mL 3.0577 mL
25 mM 0.0978 mL 0.4892 mL 0.9785 mL 2.4462 mL
30 mM 0.0815 mL 0.4077 mL 0.8154 mL 2.0385 mL
40 mM 0.0612 mL 0.3058 mL 0.6115 mL 1.5289 mL
50 mM 0.0489 mL 0.2446 mL 0.4892 mL 1.2231 mL
60 mM 0.0408 mL 0.2038 mL 0.4077 mL 1.0192 mL
80 mM 0.0306 mL 0.1529 mL 0.3058 mL 0.7644 mL
100 mM 0.0245 mL 0.1223 mL 0.2446 mL 0.6115 mL
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Olanexidine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olanexidine146509-94-6BacterialInhibitorinhibitorinhibit

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