2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. Olaptesed pegol

Olaptesed pegol (NOX-A12) L-oligoribonucleotide aptamer targeting CXCL12 based on a pegylated structure. Olaptesed pegol neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment.

For research use only. We do not sell to patients.

Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ether with RNA β-L-(G-C-G-U-G-G-U-G-U-G-A-U-C-U-A-G-A-U-G-U-A-U-U-G-G-C-U-G-A-U-C-C-U-A-G-U-C-A-G-G-U-A-C-G-C) 5′-[6-[[2-[(2-hydroxyacetyl)(2-hydroxyethyl)amino]acetyl]amino]hexyl hydrogen phosphate] (2:1)

Olaptesed pegol Chemical Structure

CAS No. : 1390628-22-4

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Description

Olaptesed pegol (NOX-A12) L-oligoribonucleotide aptamer targeting CXCL12 based on a pegylated structure. Olaptesed pegol neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment[1].

IC50 & Target

CXCL12[1]
CAS No.
SMILES

[Olaptesed pegol]
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Purity & Documentation
References
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Olaptesed pegol Related Classifications

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Keywords:

Olaptesed pegol1390628-22-4CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsPEGylated constructsL-oligonucleotidesaptamersInhibitorinhibitorinhibit

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