ONC213

Cat. No.: HY-164515 Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ONC213 is an αKGDH inhibitor that suppresses mitochondrial respiration and elevates α-ketoglutarate levels by inhibiting αKGDH activity, leading to apoptosis (Apoptosis) in AML cells. ONC213 can be used in acute myeloid leukemia research.

For research use only. We do not sell to patients.

ONC213 Chemical Structure

CAS No. : 1977540-13-8

Size	Price	Stock	Quantity
5 mg	USD 130	Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks	Estimated Time of Arrival: December 31
10 mg	USD 210	Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks	Estimated Time of Arrival: December 31
25 mg	USD 435	Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks	Estimated Time of Arrival: December 31
50 mg	USD 700	Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

Synthetic products have potential research and development risk.

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description	ONC213 is an αKGDH inhibitor that suppresses mitochondrial respiration and elevates α-ketoglutarate levels by inhibiting αKGDH activity, leading to apoptosis (Apoptosis) in AML cells. ONC213 can be used in acute myeloid leukemia research^[1].
Molecular Weight	408.44
Formula	C₂₃H₂₂F₂N₄O
CAS No.	1977540-13-8
Appearance	Solid
Color	Off-white to light yellow
SMILES	O=C1N(CC2=CC=C(F)C(F)=C2)C3=NCCN3C4=C1CN(CC4)CC5=CC=CC=C5
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation	Purity: 99.89% Select Batch: Data Sheet (266 KB) SDS (251 KB) COA (246 KB) HNMR (119 KB) LCMS (144 KB) Handling Instructions (2659 KB)
References	[1]. Su Y, et al. The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia. Cancer Res. 2024 Apr 1;84(7):1084-1100. [Content Brief]

ONC213 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ONC2131977540-13-8ONC 213ONC-213ApoptosisAcute myeloid leukemiaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

ONC213

ONC213 Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review