OXA-06 hydrochloride

Cat. No.: HY-110335 Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

OXA-06 hydrochloride is an ATP-competitive ROCK inhibitor that blocks anchorage-dependent growth and invasion of non-small cell lung cancer cell lines. OXA-06 hydrochloride inhibits cofilin phosphorylation but does not stimulate apoptosis.

For research use only. We do not sell to patients.

OXA-06 hydrochloride Chemical Structure

CAS No. : 1825455-91-1

Size	Price	Stock	Quantity
5 mg	USD 165	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 265	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 530	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of OXA-06 hydrochloride:

OXA-06 Get quote

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View All ROCK Isoform Specific Products:

View All Isoforms

ROCK ROCK1 ROCK2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

404.31

Formula

C₂₁H₂₀Cl₂FN₃

CAS No.

1825455-91-1

Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=CC=C1CNCC2=CC=C(C3=C4C(NC=C4)=NC=C3)C=C2.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (61.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4733 mL	12.3667 mL	24.7335 mL
5 mM	0.4947 mL	2.4733 mL	4.9467 mL
10 mM	0.2473 mL	1.2367 mL	2.4733 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (249 KB) HNMR (271 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Vigil D, et al. ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion. Cancer Res. 2012 Oct 15;72(20):5338-47. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4733 mL	12.3667 mL	24.7335 mL	61.8337 mL
	5 mM	0.4947 mL	2.4733 mL	4.9467 mL	12.3667 mL
	10 mM	0.2473 mL	1.2367 mL	2.4733 mL	6.1834 mL
	15 mM	0.1649 mL	0.8244 mL	1.6489 mL	4.1222 mL
	20 mM	0.1237 mL	0.6183 mL	1.2367 mL	3.0917 mL
	25 mM	0.0989 mL	0.4947 mL	0.9893 mL	2.4733 mL
	30 mM	0.0824 mL	0.4122 mL	0.8244 mL	2.0611 mL
	40 mM	0.0618 mL	0.3092 mL	0.6183 mL	1.5458 mL
	50 mM	0.0495 mL	0.2473 mL	0.4947 mL	1.2367 mL
	60 mM	0.0412 mL	0.2061 mL	0.4122 mL	1.0306 mL