Oxyfedrine hydrochloride

Name: Oxyfedrine hydrochloride
Brand: MedChemExpress
SKU: HY-108300
Rating: 4.5 (1 reviews)

Cat. No.: HY-108300 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Oxyfedrine hydrochloride, a vasodilator, is an orally active β-adrenoreceptor agonist. Oxyfedrine decreases the tonicity of coronary vessels. Oxyfedrine hydrochloride can be used in the research of cardiovascular disease.

For research use only. We do not sell to patients.

Oxyfedrine hydrochloride Chemical Structure

CAS No. : 16777-42-7

Size	Price	Stock	Quantity
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 940	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Oxyfedrine hydrochloride:

Oxyfedrine Get quote

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Oxyfedrine (50 μM, 48 h) suppresses aldehyde dehydrogenase (ALDH) activity in HCT116 and HSC-4 cells^[1].
Oxyfedrine (50 μM, 48 h) acts as a sensitizer for GSH-depleting agents, and induces cell death in HCT116 and HSC-4 cells when with the drug combinations^[1].
Oxyfedrine (0-1 μg/mL) inhibits spontaneous myogenic activity in rat isolated portal vein^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oxyfedrine (14 mg/kg, p.o., for 3-4 weeks) shows anti-anginal action in cats^[2].
Oxyfedrine (10 mg/kg, i.p., HCT116 cell xenograft mice) suppresses tumor growth when combined with sulfasalazine (SSZ, 350 mg/kg, i.p.)^[1].
Oxyfedrine (1 mg/kg, i.v.) decreases the arterial and venous blood high blood viscosity (HBV) in ice water stress rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

349.85

Formula

C₁₉H₂₄ClNO₃

CAS No.

16777-42-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC(OC)=C1)CCN[C@@H](C)[C@H](O)C2=CC=CC=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 175 mg/mL (500.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8584 mL	14.2918 mL	28.5837 mL
5 mM	0.5717 mL	2.8584 mL	5.7167 mL
10 mM	0.2858 mL	1.4292 mL	2.8584 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (246 KB) HNMR (267 KB) RP-HPLC (244 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Otsuki Y, et al. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy. Cancer Sci. 2020 Jan;111(1):127-136. [Content Brief]

[2]. Parratt JR. The haemodynamic effects of prolonged oral administration of oxyfedrine, a partial agonist at beta-adrenoceptors: comparison with propranolol. Br J Pharmacol. 1974 May;51(1):5-13. [Content Brief]

[3]. Yu J, et al. [Effects of oxyfedrine on high blood viscosity and myocardial necrosis induced by epinephrine and ice water stress in rats]. Zhongguo Yao Li Xue Bao. 1993 Jul;14(4):364-6. [Content Brief]

[4]. Mackenzie JE, et al. Effects of oxyfedrine on isolated portal vein and other smooth muscles. Br J Pharmacol. 1973 Apr;47(4):827-37. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8584 mL	14.2918 mL	28.5837 mL	71.4592 mL
	5 mM	0.5717 mL	2.8584 mL	5.7167 mL	14.2918 mL
	10 mM	0.2858 mL	1.4292 mL	2.8584 mL	7.1459 mL
	15 mM	0.1906 mL	0.9528 mL	1.9056 mL	4.7639 mL
	20 mM	0.1429 mL	0.7146 mL	1.4292 mL	3.5730 mL
	25 mM	0.1143 mL	0.5717 mL	1.1433 mL	2.8584 mL
	30 mM	0.0953 mL	0.4764 mL	0.9528 mL	2.3820 mL
	40 mM	0.0715 mL	0.3573 mL	0.7146 mL	1.7865 mL
	50 mM	0.0572 mL	0.2858 mL	0.5717 mL	1.4292 mL
	60 mM	0.0476 mL	0.2382 mL	0.4764 mL	1.1910 mL
	80 mM	0.0357 mL	0.1786 mL	0.3573 mL	0.8932 mL
	100 mM	0.0286 mL	0.1429 mL	0.2858 mL	0.7146 mL