2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial HSV Antibiotic Endogenous Metabolite
  4. Oxytetracycline dihydrate

Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity.

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Oxytetracycline dihydrate Chemical Structure

Oxytetracycline dihydrate Chemical Structure

CAS No. : 6153-64-6

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Based on 5 publication(s) in Google Scholar

Other Forms of Oxytetracycline dihydrate:

Oxytetracycline dihydrate Related Antibodies

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Description

Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity[1][2][3].

IC50 & Target[1][3]

Tetracycline

 

HSV-1

 

Bacterial

 

Microbial Metabolite

 

In Vitro

Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxytetracycline dihydrate Related Antibodies
In Vivo

The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter[1].
For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

496.46

Formula

C22H28N2O11
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])[C@@H](O)[C@]3([H])[C@](C)(O)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4)N.O.O
Structure Classification
Initial Source

Streptomyces rimosus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (100.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

1 M HCL : 10 mg/mL (20.14 mM; ultrasonic and adjust pH to 1 with 1 M HCL)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0143 mL 10.0713 mL 20.1426 mL
5 mM 0.4029 mL 2.0143 mL 4.0285 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

SDS (623 KB)

COA (258 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1 M HCL / DMSO 1 mM 2.0143 mL 10.0713 mL 20.1426 mL 50.3565 mL
5 mM 0.4029 mL 2.0143 mL 4.0285 mL 10.0713 mL
10 mM 0.2014 mL 1.0071 mL 2.0143 mL 5.0357 mL
15 mM 0.1343 mL 0.6714 mL 1.3428 mL 3.3571 mL
20 mM 0.1007 mL 0.5036 mL 1.0071 mL 2.5178 mL
DMSO 25 mM 0.0806 mL 0.4029 mL 0.8057 mL 2.0143 mL
30 mM 0.0671 mL 0.3357 mL 0.6714 mL 1.6786 mL
40 mM 0.0504 mL 0.2518 mL 0.5036 mL 1.2589 mL
50 mM 0.0403 mL 0.2014 mL 0.4029 mL 1.0071 mL
60 mM 0.0336 mL 0.1679 mL 0.3357 mL 0.8393 mL
80 mM 0.0252 mL 0.1259 mL 0.2518 mL 0.6295 mL
100 mM 0.0201 mL 0.1007 mL 0.2014 mL 0.5036 mL
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Oxytetracycline dihydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxytetracycline dihydrate6153-64-6BacterialHSVAntibioticEndogenous MetaboliteHerpes simplex virusproteinsynthesistetracyclineGram-negativeGram-positiveaminoacil-tRNAm-ribosomalHSV-1Inhibitorinhibitorinhibit

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