p-Xylene bis(pyridinium bromide) 

p-Xylene bis(pyridinium bromide) (compound 21), a cationic charged quencher, is a week bisquaternary AChE and BChE inhibitor with IC₅₀s of 1540 μM and 529 μM, respectively^[1][2].

422.16

C₁₈H₁₈Br₂N₂

14208-10-7

Solid

White to off-white

C1=CC=[N+](C=C1)CC2=CC=C(C=C2)C[N+]3=CC=CC=C3.[Br-].[Br-]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. M Smolarsky, et al. A simple fluorescent method to determine complement-mediated liposome immune lysis. J Immunol Methods. 1977;15(3):255-65.  [Content Brief]

  [2]. Kamil Musilek, et al. Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1763-6.  [Content Brief]