2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. P5(PEG24)-VC-PAB-exatecan

P5(PEG24)-VC-PAB-exatecan is a camptothecin-based linker-payload platform based on the highly potent camptothecin derivative exatecan. P5(PEG24)-VC-PAB-exatecan has linker-payload structures. P5(PEG24)-VC-PAB-exatecan can be used for the research of tumor.

For research use only. We do not sell to patients.

P5(PEG24)-VC-PAB-exatecan Chemical Structure

P5(PEG24)-VC-PAB-exatecan Chemical Structure

CAS No. : 2928571-43-9

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1 mg USD 1090 In-stock
5 mg USD 2400 In-stock
10 mg USD 3850 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

P5(PEG24)-VC-PAB-exatecan Related Antibodies

Top Publications Citing Use of Products

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

P5(PEG24)-VC-PAB-exatecan is a camptothecin-based linker-payload platform based on the highly potent camptothecin derivative exatecan. P5(PEG24)-VC-PAB-exatecan has linker-payload structures. P5(PEG24)-VC-PAB-exatecan can be used for the research of tumor[1].

IC50 & Target

Camptothecins

 

Molecular Weight

2105.31

Formula

C100H151FN9O36P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(C#C)(NC1=CC=C(C=C1)C(N[C@@H](C(C)C)C(N[C@H](C(NC2=CC=C(C=C2)COC(N[C@H]3CCC4=C5C(N=C6C7=CC8=C(C(N7CC6=C53)=O)COC([C@@]8(CC)O)=O)=CC(F)=C4C)=O)=O)CCCNC(N)=O)=O)=O)OCCOCCO.[23]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (47.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4750 mL 2.3749 mL 4.7499 mL
5 mM 0.0950 mL 0.4750 mL 0.9500 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.74%

SDS (252 KB)

COA (249 KB) HNMR (327 KB) RP-HPLC (263 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4750 mL 2.3749 mL 4.7499 mL 11.8747 mL
5 mM 0.0950 mL 0.4750 mL 0.9500 mL 2.3749 mL
10 mM 0.0475 mL 0.2375 mL 0.4750 mL 1.1875 mL
15 mM 0.0317 mL 0.1583 mL 0.3167 mL 0.7916 mL
20 mM 0.0237 mL 0.1187 mL 0.2375 mL 0.5937 mL
25 mM 0.0190 mL 0.0950 mL 0.1900 mL 0.4750 mL
30 mM 0.0158 mL 0.0792 mL 0.1583 mL 0.3958 mL
40 mM 0.0119 mL 0.0594 mL 0.1187 mL 0.2969 mL
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P5(PEG24)-VC-PAB-exatecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P5(PEG24)-VC-PAB-exatecan2928571-43-9Drug-Linker Conjugates for ADCTopoisomerasecamptothecin-basedlinker-payload platformtumorInhibitorinhibitorinhibit

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