2. Immunology/Inflammation
  3. CD3
  4. Pasotuxizumab

Pasotuxizumab  (Synonyms: BAY 2010112; AMG 212)

Cat. No.: HY-P99802 Purity: 98.02%
COA

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Pasotuxizumab (BAY 2010112) is a PSMA and CD3 bispecific T-cell engager (BiTE). Pasotuxizumab binds to CD3 and PSMA with KDs of 9.4 nM and 47.0 nM for human CD3 and PSMA. Pasotuxizumab can be used for research of metastatic castration-resistant prostate cancer (mCRPC).

For research use only. We do not sell to patients.

CAS No. : 1442657-12-6

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Based on 1 publication(s) in Google Scholar

Pasotuxizumab Related Antibodies

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Description

Pasotuxizumab (BAY 2010112) is a PSMA and CD3 bispecific T-cell engager (BiTE). Pasotuxizumab binds to CD3 and PSMA with KDs of 9.4 nM and 47.0 nM for human CD3 and PSMA. Pasotuxizumab can be used for research of metastatic castration-resistant prostate cancer (mCRPC)[1][2].

Isotype

(scFv-heavy-kappa)-(scFv-heavy-lambda)
Species

Chimeric; Humanized
IC50 & Target

KDs: 9.4 nM and 16.3 nM for human and cynomolgus monkey CD3.
KDs: 47.0 nM and 212.6 nM for human and cynomolgus monkey PSMA.
In Vitro

Pasotuxizumab (0-100 ng/mL approximately, 48 h) leads to activation of CD4+ and CD8+ T cell populations, with EC50s of 3.4-6.7 ng/mL for human cocultures, and 13.7-21.2 ng/mL for cynomolgus monkey cell cocultures[2].
Pasotuxizumab (0-100 ng/mL approximately, 48 h) increases release of interferon-γ, TNF-α, IL-2 and IL-10 in T cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pasotuxizumab Related Antibodies
In Vivo

Pasotuxizumab (0-100 ng/mL approximately, 48 h) leads to activation of CD4+ and CD8+ T cell populations, with EC50s of 3.4-6.7 ng/mL for human cocultures, and 13.7-21.2 ng/mL for cynomolgus monkey cell cocultures[2].
Pasotuxizumab (0-100 ng/mL approximately, 48 h) increases release of interferon-γ, TNF-α, IL-2 and IL-10 in T cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PC-3-huPSMA mouse xenograft model[2]
Dosage: 0.005-5 mg/kg
Administration: i.v., once daily
Result: Inhibited tumor growth by 86% (0.005 mg/kg/d) and 99% (5 mg/kg/d).
Animal Model: BALB/c mice (PK Assay)[2]
Dosage: 0.1, 0.3, and 1 mg/kg
Administration: i.v. bolus administration or s.c.
Result: Pharmacokinetic profile of Rafivirumab.
Dose (mg/kg) AUC (mg h/L) CLmatrix (L/h/kg) T1/2 (h) F (%)
i.v. (0.3) 0.93 0.32 9.7 100
s.c. (0.3) 0.17 11 18
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Pasotuxizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • (scFv-heavy-kappa)-(scFv-heavy-lambda)
Purity & Documentation
References
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  • If you have published this work, please enter the PubMed ID.
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Pasotuxizumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pasotuxizumab1442657-12-6BAY 2010112 AMG 212BAY2010112BAY-2010112AMG212AMG 212AMG-212CD3Cluster of differentiation 3mCRPCcancerT-cellBiTEPC-3prostate cancerInhibitorinhibitorinhibit

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