2. Immunology/Inflammation
  3. CD3
  4. Pavurutamab

Pavurutamab  (Synonyms: AMG-701)

Cat. No.: HY-P99814 Purity: 95.70%
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Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti-CD3 and anti-B cell maturation antigens (BCMA). Pavurutamab has an extended half-life based on Pacanalotamab (HY-P99798). The Fc of Pavurutamab is coupled to molecules to improve pharmacokinetic parameters. Pavurutamab has potential applications in immune regulation and multiple myeloma (MM).

For research use only. We do not sell to patients.

CAS No. : 2250292-39-6

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Based on 1 publication(s) in Google Scholar

Pavurutamab Related Antibodies

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Description

Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti-CD3 and anti-B cell maturation antigens (BCMA). Pavurutamab has an extended half-life based on Pacanalotamab (HY-P99798). The Fc of Pavurutamab is coupled to molecules to improve pharmacokinetic parameters. Pavurutamab has potential applications in immune regulation and multiple myeloma (MM)[1][2][3][4].

Isotype

(scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc
Species

Chimeric; Humanized
IC50 & Target

B cell maturation antigens, BCMA[1]
In Vitro

Pavurutamab (0-10000 pM; 48 h) induces CD69+, CD25+ T cell activation and IFNγ, TNFα, IL-2, IL-4, IL-6, IL-10 cytokine secretion[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pavurutamab Related Antibodies
In Vivo

Pavurutamab (0.02, 0.2 and 2 mg/kg; i.v.; single dose on days 3, 8, 13) reduces tumor volume with time and dose dependent manner in mouse xenograft models[5].
Pavurutamab (0.005, 0.05 and 0.5 mg/kg; i.v.; every 5 days for 6 administrations, lasting for 30 days) reduces tumor volume and increases survival with time and dose dependent manner in NOD/SCID mice transplanted with L-363 multiple myeloma (MM) cells[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/SCID mice transplanted with NCI-H929 MM cells mixed with PBMCs[5].
Dosage: 0.02, 0.2 and 2 mg/kg.
Administration: Intravenous injection; single dose on days 3, 8, 13.
Result: Reduced tumor volume.
Animal Model: NOD/SCID mice orthotopically transplanted with L-363 MM cells[5].
Dosage: 0.005, 0.05 and 0.5 mg/kg.
Administration: Intravenous injection; every 5 days for 6 administrations, starting from day 9 and lasting for 30 days.
Result: Reduced tumor volume and increased survival.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Pavurutamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • (scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc
Biological Activity
  • Immobilized Pavurutamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 1.26 ng/mL.
  • Immobilized Pavurutamab can bind Human BCMA Protein (ECD, His Tag). The EC50 for this effect is 0.194 ng/mL.
Purity & Documentation
References
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Pavurutamab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pavurutamab2250292-39-6AMG-701AMG701AMG 701CD3Cluster of differentiation 3NOD/SCID miceCD69+ T cellCD25+ T cellMultiple MyelomaMMInhibitorinhibitorinhibit

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