2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. pCXCL8-1aa

pCXCL8-1aa is an anti-inflammatory peptide. pCXCL8-1aa competitively inhibits the binding of CXCL8 to glycosaminoglycans such as heparin sulfate (HS) by binding with high affinity. This reduces the presentation of CXCL8 on the surface of vascular endothelial cells, thereby inhibiting neutrophil migration and inflammatory responses. pCXCL8-1aa can be used to study inflammatory diseases such as rheumatoid arthritis.

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Custom Peptide Synthesis

pCXCL8-1aa Chemical Structure

pCXCL8-1aa Chemical Structure

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Based on 1 publication(s) in Google Scholar

pCXCL8-1aa Related Antibodies

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Description

pCXCL8-1aa is an anti-inflammatory peptide. pCXCL8-1aa competitively inhibits the binding of CXCL8 to glycosaminoglycans such as heparin sulfate (HS) by binding with high affinity. This reduces the presentation of CXCL8 on the surface of vascular endothelial cells, thereby inhibiting neutrophil migration and inflammatory responses. pCXCL8-1aa can be used to study inflammatory diseases such as rheumatoid arthritis[1].

Molecular Weight

1262.41

Formula

C55H91N17O17
Appearance

Solid

Color

White to off-white

Sequence

Ac-Glu-Lys-Phe-Leu-Lys-Arg-Ala-Glu-Asn-Ser-NH2
Sequence Shortening

Ac-EKFLKRAENS-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (79.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7921 mL 3.9607 mL 7.9214 mL
5 mM 0.1584 mL 0.7921 mL 1.5843 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7921 mL 3.9607 mL 7.9214 mL 19.8034 mL
5 mM 0.1584 mL 0.7921 mL 1.5843 mL 3.9607 mL
10 mM 0.0792 mL 0.3961 mL 0.7921 mL 1.9803 mL
15 mM 0.0528 mL 0.2640 mL 0.5281 mL 1.3202 mL
20 mM 0.0396 mL 0.1980 mL 0.3961 mL 0.9902 mL
25 mM 0.0317 mL 0.1584 mL 0.3169 mL 0.7921 mL
30 mM 0.0264 mL 0.1320 mL 0.2640 mL 0.6601 mL
40 mM 0.0198 mL 0.0990 mL 0.1980 mL 0.4951 mL
50 mM 0.0158 mL 0.0792 mL 0.1584 mL 0.3961 mL
60 mM 0.0132 mL 0.0660 mL 0.1320 mL 0.3301 mL
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pCXCL8-1aa Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

pCXCL8-1aaCXCRCXC chemokine receptorsC-X-C motif chemokine receptorsAnti-inflammatory peptideGlycosaminoglycanRheumatoid arthritisCompetitive inhibitionCXCL8Inhibitorinhibitorinhibit

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