PD 4'-oxyacetic acid

Cat. No.: HY-W761299 Purity: 99.69%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

PD 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC Degrader development.

For research use only. We do not sell to patients.

PD 4'-oxyacetic acid Chemical Structure

CAS No. : 2633633-12-0

Size	Stock	Quantity
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	Get quote	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

Biological Activity
Purity & Documentation
References
Customer Review

Description

PD 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC Degrader development^[1].

IC₅₀ & Target

Cereblon

Molecular Weight

264.24

Formula

C₁₂H₁₂N₂O₅

CAS No.

2633633-12-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COC1=CC=C(N(C(N2)=O)CCC2=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (47.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7845 mL	18.9224 mL	37.8448 mL
5 mM	0.7569 mL	3.7845 mL	7.5690 mL
10 mM	0.3784 mL	1.8922 mL	3.7845 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.69%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (247 KB) HNMR (120 KB) RP-HPLC (160 KB)

Handling Instructions (2659 KB)

References

[1]. Jarusiewicz JA, et al. Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design. ACS Med Chem Lett. 2023;14(2):141-145. Published 2023 Jan 4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7845 mL	18.9224 mL	37.8448 mL	94.6120 mL
	5 mM	0.7569 mL	3.7845 mL	7.5690 mL	18.9224 mL
	10 mM	0.3784 mL	1.8922 mL	3.7845 mL	9.4612 mL
	15 mM	0.2523 mL	1.2615 mL	2.5230 mL	6.3075 mL
	20 mM	0.1892 mL	0.9461 mL	1.8922 mL	4.7306 mL
	25 mM	0.1514 mL	0.7569 mL	1.5138 mL	3.7845 mL
	30 mM	0.1261 mL	0.6307 mL	1.2615 mL	3.1537 mL
	40 mM	0.0946 mL	0.4731 mL	0.9461 mL	2.3653 mL