PD 4'-oxyacetic acid

Cat. No.: HY-W761299 Purity: 99.69%: FAQs
Data Sheet SDS COA Handling Instructions

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PD 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC Degrader development.

For research use only. We do not sell to patients.

PD 4'-oxyacetic acid Chemical Structure

CAS No. : 2633633-12-0

Size	Price	Stock	Quantity
10 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 85	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 215	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 360	Get quote	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

Biological Activity
Purity & Documentation
References
Customer Review

Description

PD 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC Degrader development^[1].

Molecular Weight

264.23

Formula

C₁₂H₁₂N₂O₅

CAS No.

2633633-12-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COC1=CC=C(N(C(N2)=O)CCC2=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (47.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7846 mL	18.9229 mL	37.8458 mL
5 mM	0.7569 mL	3.7846 mL	7.5692 mL
10 mM	0.3785 mL	1.8923 mL	3.7846 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.69%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (247 KB) HNMR (120 KB) RP-HPLC (160 KB)

Handling Instructions (2659 KB)

References

[1]. Jarusiewicz JA, et al. Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design. ACS Med Chem Lett. 2023;14(2):141-145. Published 2023 Jan 4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7846 mL	18.9229 mL	37.8458 mL	94.6145 mL
	5 mM	0.7569 mL	3.7846 mL	7.5692 mL	18.9229 mL
	10 mM	0.3785 mL	1.8923 mL	3.7846 mL	9.4615 mL
	15 mM	0.2523 mL	1.2615 mL	2.5231 mL	6.3076 mL
	20 mM	0.1892 mL	0.9461 mL	1.8923 mL	4.7307 mL
	25 mM	0.1514 mL	0.7569 mL	1.5138 mL	3.7846 mL
	30 mM	0.1262 mL	0.6308 mL	1.2615 mL	3.1538 mL
	40 mM	0.0946 mL	0.4731 mL	0.9461 mL	2.3654 mL