2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PDE5-IN-9

PDE5-IN-9 (Compound 59) is a PDE5 inhibitor (IC50: 11.2 μM). PDE5-IN-9 shows interaction with Gln 817, Tyr 612, and Ala 767 amino acid residues. PDE5-IN-9 can be used for research of cardiovascular disease.

For research use only. We do not sell to patients.

PDE5-IN-9 Chemical Structure

PDE5-IN-9 Chemical Structure

CAS No. : 157862-84-5

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10 mg USD 90 In-stock
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Based on 1 publication(s) in Google Scholar

PDE5-IN-9 Related Antibodies

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Description

PDE5-IN-9 (Compound 59) is a PDE5 inhibitor (IC50: 11.2 μM). PDE5-IN-9 shows interaction with Gln 817, Tyr 612, and Ala 767 amino acid residues. PDE5-IN-9 can be used for research of cardiovascular disease[1].

IC50 & Target

PDE5

 

Molecular Weight

318.40

Formula

C18H14N4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C1(C2=CC=CN=C2)=NC(NCC3=CC=CS3)=C4C=CC=CC4=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (314.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1407 mL 15.7035 mL 31.4070 mL
5 mM 0.6281 mL 3.1407 mL 6.2814 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1407 mL 15.7035 mL 31.4070 mL 78.5176 mL
5 mM 0.6281 mL 3.1407 mL 6.2814 mL 15.7035 mL
10 mM 0.3141 mL 1.5704 mL 3.1407 mL 7.8518 mL
15 mM 0.2094 mL 1.0469 mL 2.0938 mL 5.2345 mL
20 mM 0.1570 mL 0.7852 mL 1.5704 mL 3.9259 mL
25 mM 0.1256 mL 0.6281 mL 1.2563 mL 3.1407 mL
30 mM 0.1047 mL 0.5235 mL 1.0469 mL 2.6173 mL
40 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9629 mL
50 mM 0.0628 mL 0.3141 mL 0.6281 mL 1.5704 mL
60 mM 0.0523 mL 0.2617 mL 0.5235 mL 1.3086 mL
80 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9815 mL
100 mM 0.0314 mL 0.1570 mL 0.3141 mL 0.7852 mL
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PDE5-IN-9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE5-IN-9157862-84-5Phosphodiesterase (PDE)Cardiovascular diseasehypertensionInhibitorinhibitorinhibit

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