2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PDE7-IN-2

PDE7-IN-2 (compound 2) is a potent PDE7 (phosphodiesterase 7) inhibitor with IC50 value of 2.1 µM. PDE7-IN-2 has the potential for the research of parkinson’s disease.

For research use only. We do not sell to patients.

PDE7-IN-2 Chemical Structure

PDE7-IN-2 Chemical Structure

CAS No. : 107522-19-0

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Customer Review

Based on 1 publication(s) in Google Scholar

PDE7-IN-2 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

PDE7-IN-2 (compound 2) is a potent PDE7 (phosphodiesterase 7) inhibitor with IC50 value of 2.1 µM. PDE7-IN-2 has the potential for the research of parkinson’s disease[1].

IC50 & Target[1]

PDE7A

2.1 μM (IC50)

Molecular Weight

322.77

Formula

C14H11ClN2O3S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

ClC1=CC(SC2=CC=CC=C2NC(C)=O)=C(C=C1)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (92.95 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0982 mL 15.4909 mL 30.9818 mL
5 mM 0.6196 mL 3.0982 mL 6.1964 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0982 mL 15.4909 mL 30.9818 mL 77.4545 mL
5 mM 0.6196 mL 3.0982 mL 6.1964 mL 15.4909 mL
10 mM 0.3098 mL 1.5491 mL 3.0982 mL 7.7455 mL
15 mM 0.2065 mL 1.0327 mL 2.0655 mL 5.1636 mL
20 mM 0.1549 mL 0.7745 mL 1.5491 mL 3.8727 mL
25 mM 0.1239 mL 0.6196 mL 1.2393 mL 3.0982 mL
30 mM 0.1033 mL 0.5164 mL 1.0327 mL 2.5818 mL
40 mM 0.0775 mL 0.3873 mL 0.7745 mL 1.9364 mL
50 mM 0.0620 mL 0.3098 mL 0.6196 mL 1.5491 mL
60 mM 0.0516 mL 0.2582 mL 0.5164 mL 1.2909 mL
80 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.9682 mL
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PDE7-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE7-IN-2107522-19-0Phosphodiesterase (PDE)parkinson’s diseasesulfidesSH-SY5Y cellsno antioxidant activityprotein kinaseInhibitorinhibitorinhibit

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