PDM11

Cat. No.: HY-112554 Purity: 99.93%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

PDM11 is a derivative of antioxidant resveratrol. PDM11 do not exhibit any significant protective effect against oxidation of linoleate micelles initiated by radiolysis-generated hydroxyl radicals. PDM11 is inactive in resveratrol activity assays.

For research use only. We do not sell to patients.

PDM11 Chemical Structure

CAS No. : 1032508-03-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	> 10 μM Compound: 19	Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay	[PMID: 20627379]
HT-29	IC₅₀	> 10 μM Compound: 19	Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay	[PMID: 20627379]

Molecular Weight

274.74

Formula

C₁₆H₁₅ClO₂

CAS No.

1032508-03-4

Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (181.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6398 mL	18.1990 mL	36.3981 mL
5 mM	0.7280 mL	3.6398 mL	7.2796 mL
10 mM	0.3640 mL	1.8199 mL	3.6398 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.93%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (245 KB) HNMR (248 KB) RP-HPLC (178 KB)

Handling Instructions (2659 KB)

References

[1]. Kondratyuk TP, et al. Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Mol Nutr Food Res. 2011;55(8):1249-1265. [Content Brief]

[2]. Rhayem Y, et al. Chain-breaking activity of resveratrol and piceatannol in a linoleate micellar model. Chem Phys Lipids. 2008;155(1):48-56. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6398 mL	18.1990 mL	36.3981 mL	90.9951 mL
	5 mM	0.7280 mL	3.6398 mL	7.2796 mL	18.1990 mL
	10 mM	0.3640 mL	1.8199 mL	3.6398 mL	9.0995 mL
	15 mM	0.2427 mL	1.2133 mL	2.4265 mL	6.0663 mL
	20 mM	0.1820 mL	0.9100 mL	1.8199 mL	4.5498 mL
	25 mM	0.1456 mL	0.7280 mL	1.4559 mL	3.6398 mL
	30 mM	0.1213 mL	0.6066 mL	1.2133 mL	3.0332 mL
	40 mM	0.0910 mL	0.4550 mL	0.9100 mL	2.2749 mL
	50 mM	0.0728 mL	0.3640 mL	0.7280 mL	1.8199 mL
	60 mM	0.0607 mL	0.3033 mL	0.6066 mL	1.5166 mL
	80 mM	0.0455 mL	0.2275 mL	0.4550 mL	1.1374 mL
	100 mM	0.0364 mL	0.1820 mL	0.3640 mL	0.9100 mL

PDM11 Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDM111032508-03-4PDM 11PDM-11PhosphataseInhibitorinhibitorinhibit

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PDM11

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