2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. PE154

PE154 (Compound 13) is a potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50s=280 pM and 16 nM, respectively). PE154 can label β-amyloid plaques in histochemical analysis.

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PE154 Chemical Structure

PE154 Chemical Structure

CAS No. : 1192750-33-6

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Description

PE154 (Compound 13) is a potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50s=280 pM and 16 nM, respectively)[1]. PE154 can label β-amyloid plaques in histochemical analysis[2].

IC50 & Target

BChE

16 nM (IC50)

AChE

280 pM (IC50)

In Vivo

PE154 (hippocampus injection; 0.2 μg per mouse; once) can stain the histochemical of cortical βamyloid plaques[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 13–20-month-old triple-transgenic mice harbouring three mutant genes (APPswe, PS-1 and tauP301L)[2]
Dosage: 0.2 μg per mouse
Administration: Hippocampus injection; 0.2 μg per mouse; once
Result: Showed the histochemical staining of cortical βamyloid plaques in triple-transgenic (TTG) mice.
Molecular Weight

589.68

Formula

C35H35N5O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

Emission (Em)

512
Excitation (Ex)

467
SMILES

O=C(NNC1=C(CCCC2)C2=NC3=CC=CC=C31)CC4=CC=C(N/C=C(C(C5=CC=C(N(CC)CC)C=C5O6)=O)/C6=O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (14.13 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6958 mL 8.4792 mL 16.9583 mL
5 mM 0.3392 mL 1.6958 mL 3.3917 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6958 mL 8.4792 mL 16.9584 mL 42.3959 mL
5 mM 0.3392 mL 1.6958 mL 3.3917 mL 8.4792 mL
10 mM 0.1696 mL 0.8479 mL 1.6958 mL 4.2396 mL
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PE154 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PE1541192750-33-6PE 154PE-154Cholinesterase (ChE)β-amyloidfluorescenthistochemical analysisInhibitorinhibitorinhibit

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