2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Pebezertinib

Pebezertinib  (Synonyms: BLU 451; LNG-451)

Cat. No.: HY-164307 Purity: 99.56%
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Pebezertinib (BLU 451) is an orally active inhibitor for EGFR. Pebezertinib exhibits the ability to penetrate the central nervous system (CNS). Pebezertinib can be used for research about non-small cell lung cancer carrying EGFR exon 20 insertion.

For research use only. We do not sell to patients.

Pebezertinib Chemical Structure

Pebezertinib Chemical Structure

CAS No. : 2769954-39-2

Size Price Stock Quantity
5 mg USD 190 In-stock
10 mg USD 275 In-stock
25 mg USD 470 In-stock
50 mg USD 680 In-stock
100 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

Pebezertinib Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

Pebezertinib (BLU 451) is an orally active inhibitor for EGFR. Pebezertinib exhibits the ability to penetrate the central nervous system (CNS). Pebezertinib can be used for research about non-small cell lung cancer carrying EGFR exon 20 insertion[1].

Molecular Weight

497.45

Formula

C24H19F4N7O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(C(NC2=C(C3=CC=C(C(F)(F)F)C=C3)C=NC(NC4=CN(C)N=C4)=N2)=C1)F)C=C
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (234.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0103 mL 10.0513 mL 20.1025 mL
5 mM 0.4021 mL 2.0103 mL 4.0205 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0103 mL 10.0513 mL 20.1025 mL 50.2563 mL
5 mM 0.4021 mL 2.0103 mL 4.0205 mL 10.0513 mL
10 mM 0.2010 mL 1.0051 mL 2.0103 mL 5.0256 mL
15 mM 0.1340 mL 0.6701 mL 1.3402 mL 3.3504 mL
20 mM 0.1005 mL 0.5026 mL 1.0051 mL 2.5128 mL
25 mM 0.0804 mL 0.4021 mL 0.8041 mL 2.0103 mL
30 mM 0.0670 mL 0.3350 mL 0.6701 mL 1.6752 mL
40 mM 0.0503 mL 0.2513 mL 0.5026 mL 1.2564 mL
50 mM 0.0402 mL 0.2010 mL 0.4021 mL 1.0051 mL
60 mM 0.0335 mL 0.1675 mL 0.3350 mL 0.8376 mL
80 mM 0.0251 mL 0.1256 mL 0.2513 mL 0.6282 mL
100 mM 0.0201 mL 0.1005 mL 0.2010 mL 0.5026 mL
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Pebezertinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pebezertinib2769954-39-2BLU 451 LNG-451BLU451BLU-451LNG451LNG 451LNG-451EGFREpidermal growth factor receptorErbB-1HER1Non-small cell lung cancerNSCLCorally activeInhibitorinhibitorinhibit

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