Penciclovir-d₄ (Synonyms: BRL 39123-d₄; VSA 671-d₄)

Cat. No.: HY-17424S: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Penciclovir-d₄ is the deuterium labeled Penciclovir. Penciclovir is reported to be potent against HSV types 1 and 2 with IC50 of 0.04-1.8 μg/mL and 0.06-4.4 μg/mL, respectively[1][2].

For research use only. We do not sell to patients.

Penciclovir-d<sub>4</sub> Chemical Structure

Penciclovir-d₄ Chemical Structure

CAS No. : 1020719-72-5

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500 μg	USD 150	Ask For Quote & Lead Time

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Other Forms of Penciclovir-d₄:

Penciclovir In-stock

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HSV-1 HSV-2 HSV

Biological Activity
Purity & Documentation
References
Customer Review

Description

Penciclovir-d₄ is the deuterium labeled Penciclovir. Penciclovir is reported to be potent against HSV types 1 and 2 with IC50 of 0.04-1.8 μg/mL and 0.06-4.4 μg/mL, respectively[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

257.28

Formula

C₁₀H₁₁D₄N₅O₃

CAS No.

1020719-72-5

Unlabeled CAS

39809-25-1

Appearance

Solid

Color

White to light yellow

SMILES

OCC(CO)C([2H])([2H])C([2H])([2H])N1C2=C(C(N=C(N2)N)=O)N=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (97.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 2 mg/mL (7.77 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8868 mL	19.4341 mL	38.8682 mL
5 mM	0.7774 mL	3.8868 mL	7.7736 mL
10 mM	0.3887 mL	1.9434 mL	3.8868 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (253 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Piret J, et al. Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management. Antimicrob Agents Chemother. 2011 Feb;55(2):459-72. [Content Brief]

[3]. Xiong Z, et al. Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living micewith mutant herpes simplex virus type 1 thymidine kinase PET reporter gene. J Nucl Med. 2006 Jan;47(1):130-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O / DMSO / DMSO	1 mM	3.8868 mL	19.4341 mL	38.8682 mL	97.1704 mL
H₂O / H₂O / DMSO / DMSO	5 mM	0.7774 mL	3.8868 mL	7.7736 mL	19.4341 mL
DMSO / DMSO	10 mM	0.3887 mL	1.9434 mL	3.8868 mL	9.7170 mL
	15 mM	0.2591 mL	1.2956 mL	2.5912 mL	6.4780 mL
	20 mM	0.1943 mL	0.9717 mL	1.9434 mL	4.8585 mL
	25 mM	0.1555 mL	0.7774 mL	1.5547 mL	3.8868 mL
	30 mM	0.1296 mL	0.6478 mL	1.2956 mL	3.2390 mL
	40 mM	0.0972 mL	0.4859 mL	0.9717 mL	2.4293 mL
	50 mM	0.0777 mL	0.3887 mL	0.7774 mL	1.9434 mL
	60 mM	0.0648 mL	0.3239 mL	0.6478 mL	1.6195 mL
	80 mM	0.0486 mL	0.2429 mL	0.4859 mL	1.2146 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Penciclovir-d₄ Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penciclovir-d₄1020719-72-5BRL 39123-d₄VSA 671-d₄Isotope-Labeled CompoundsHSVHerpes simplex virusInhibitorinhibitorinhibit

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Penciclovir-d4 (Synonyms: BRL 39123-d4; VSA 671-d4)

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