Penicillin V  (Synonyms: Phenoxymethylpenicillin)

Penicillin V (Phenoxymethylpenicillin) is a potent and orally active antibiotic. Penicillin V shows antibacterial activity for Streptococci, Clostridium difficile and staphylococcus aureus. Penicillin V has the potential for the research of otitis, sinusitis, pharyngitis and tonsillitis^[1][2][3][4].

Penicillin V (0.002-8.0 mg/L) inhibits the growth of Streptococci, with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L^[2].
Penicillin V (0.002-8.0 mg/L) shows antibacterial activity for Clostridium difficile with an MIC₅₀ value of 4.0 mg/L and an MIC₉₀ value of 8.0 mg/L^[3].
Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of Staphylococcus aureus, with an MIC value of 0.016 mg/L^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Penicillin V (0.063-0.25 mg/kg; s.c.) inhibits the outgrowth of S. aureus in mice thigh muscle^[4].
Penicillin V (2 mg/kg; s.c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L·h)^[4].
Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

350.39

C₁₆H₁₈N₂O₅S

87-08-1

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(COC3=CC=CC=C3)=O)N1C2=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sabath LD. Et, al. Phenoxymethylpenicillin (penicillin V) and phenethicillin. Med Clin North Am. 1970 Sep;54(5):1101-11.  [Content Brief]

  [2]. Kamme C, et, al. In vitro effect on group A streptococci of loracarbef versus cefadroxil, cefaclor and penicillin V. Scand J Infect Dis. 1993;25(1):37-42.  [Content Brief]

  [3]. Norén T, et, al. In vitro susceptibility to 17 antimicrobials of clinical Clostridium difficile isolates collected in 1993-2007 in Sweden. Clin Microbiol Infect. 2010 Aug;16(8):1104-10.  [Content Brief]

  [4]. Overbosch D, et, al. Comparative pharmacodynamics and clinical pharmacokinetics of phenoxymethylpenicillin and pheneticillin. Br J Clin Pharmacol. 1985 May;19(5):657-68.  [Content Brief]

  [5]. Hermansson A, et, al. Prevention of experimental acute otitis media with penicillin V. Acta Otolaryngol. Jan-Feb 1990;109(1-2):119-23.  [Content Brief]

  [6]. Timm A, et al. Photolysis of four β‑lactam antibiotics under simulated environmental conditions: Degradation, transformation products and antibacterial activity. Sci Total Environ. 2019 Feb 15;651(Pt 1):1605-1612.  [Content Brief]