Perindoprilat (Synonyms: S 9780)

Name: Perindoprilat
Brand: MedChemExpress
SKU: HY-B1433
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1433 Purity: 99.60%: FAQs
Data Sheet SDS COA Handling Instructions

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Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC₅₀ value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research.

For research use only. We do not sell to patients.

Perindoprilat Chemical Structure

CAS No. : 95153-31-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 37	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 37	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Perindoprilat:

Perindoprilat-d₃ disodium Get quote

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Description

Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC₅₀ value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research^[1]^[2].

In Vitro

Perindoprilat (1 μM, 10 days) treatment suppresses the angiotensin II production in HNSCC cells^[2]. Perindoprilat (40 μM, 3 days) treatment attenuates mesangial cell fibronectin level^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	HNSCC cells
Concentration:	1 μM
Incubation Time:	10 days
Result:	Suppressed the angiotensin II production in HNSCC cells (P=0.028).

Cell Viability Assay^[3]

Cell Line:	Human mesangial cells
Concentration:	40 μM
Incubation Time:	3 days
Result:	Resulted in decreases in MPCM-stimulated fibronectin levels of 19.4±0.6% (P<0.001) and 21.7±1.0% (P<0.001) for secreted and cell-associated fibronectin levels, respectively.

In Vivo

Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment improves cardiac function in mice with acute myocardial infarction and reduces the number of apoptotic myocardial cells^[4].
Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment reduces the expression levels of myocardial Bax and Bcl-2 in infarction zones of mice with acute myocardial infarction^[4].
Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment lowers the expression of myocardial TLR4/NF-κB in infarction zones in mice with acute myocardial infarction^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice underwent coronary ligation^[4]
Dosage:	1.5 mg/kg
Administration:	Oral gavage; 1.5 mg/kg; once daily; 7 days
Result:	Exhibited markedly lowered the number of apoptotic myocardial cells in comparison with the acute myocardial infarction group (p<0.05).

Animal Model:	C57BL/6J mice underwent coronary ligation^[4]
Dosage:	1.5 mg/kg
Administration:	Oral gavage; 1.5 mg/kg; once daily; 7 days
Result:	Reduced the gene and protein expression levels of Bax (a myocardial apoptosis gene) in infarction zones in mice with acute myocardial infarction.

Animal Model:	C57BL/6J mice underwent coronary ligation^[4]
Dosage:	1.5 mg/kg
Administration:	Oral gavage; 1.5 mg/kg; once daily; 7 days
Result:	Declined the number of stained NF-κB p50 protein in the nucleus in infarction zones (p<0.05), compared to the acute myocardial infarction group.

Molecular Weight

340.41

Formula

C₁₇H₂₈N₂O₅

CAS No.

95153-31-4

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1N(C([C@@H](N[C@H](C(O)=O)CCC)C)=O)[C@@]2([H])CCCC[C@@]2([H])C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H₂O : 175 mg/mL (514.09 mM; Need ultrasonic)

DMSO : 100 mg/mL (293.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9376 mL	14.6882 mL	29.3763 mL
5 mM	0.5875 mL	2.9376 mL	5.8753 mL
10 mM	0.2938 mL	1.4688 mL	2.9376 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.60%

Select Batch:

Data Sheet (282 KB) SDS (393 KB)

COA (255 KB) HNMR (288 KB) RP-HPLC (222 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Perindopril. Expert Opin Pharmacother. 2006 Jan;7(1):63-71. [Content Brief]

[2]. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6. [Content Brief]

[3]. Izabella Z A Pawluczyk, et al. The role of bradykinin in the antifibrotic actions of perindoprilat on human mesangial cells. Kidney Int. 2004 Apr;65(4):1240-51. [Content Brief]

[4]. X-Z Wang, et al. Perindopril inhibits myocardial apoptosis in mice with acute myocardial infarction through TLR4/NF-κB pathway. Eur Rev Med Pharmacol Sci. 2019 Aug;23(15):6672-6682. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.9376 mL	14.6882 mL	29.3763 mL	73.4408 mL
	5 mM	0.5875 mL	2.9376 mL	5.8753 mL	14.6882 mL
	10 mM	0.2938 mL	1.4688 mL	2.9376 mL	7.3441 mL
	15 mM	0.1958 mL	0.9792 mL	1.9584 mL	4.8961 mL
	20 mM	0.1469 mL	0.7344 mL	1.4688 mL	3.6720 mL
	25 mM	0.1175 mL	0.5875 mL	1.1751 mL	2.9376 mL
	30 mM	0.0979 mL	0.4896 mL	0.9792 mL	2.4480 mL
	40 mM	0.0734 mL	0.3672 mL	0.7344 mL	1.8360 mL
	50 mM	0.0588 mL	0.2938 mL	0.5875 mL	1.4688 mL
	60 mM	0.0490 mL	0.2448 mL	0.4896 mL	1.2240 mL
	80 mM	0.0367 mL	0.1836 mL	0.3672 mL	0.9180 mL
	100 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.7344 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Perindoprilat Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perindoprilat95153-31-4S 9780S9780S-9780Angiotensin-converting Enzyme (ACE)hypertensionACE inhibitorangiotensin-converting enzymeHNSCCInhibitorinhibitorinhibit

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Perindoprilat (Synonyms: S 9780)

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Complete Stock Solution Preparation Table

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