Perphenazine-d₄

Name: Perphenazine-d 4
Brand: MedChemExpress
SKU: HY-A0077S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-A0077S1 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Perphenazine-d₄ is the deuterium labeled Perphenazine. Perphenazine is a typical antipsychotic agent, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.

For research use only. We do not sell to patients.

Perphenazine-d<sub>4</sub> Chemical Structure

Perphenazine-d₄ Chemical Structure

CAS No. : 155593-75-2

Size	Price	Stock	Quantity
1 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Perphenazine-d₄:

Perphenazine In-stock
Perphenazine-d₆ fumarate Get quote

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•Related Small Molecules:

•Related Proteins:

View All Dopamine Receptor Isoform Specific Products:

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

View All Adrenergic Receptor Isoform Specific Products:

View All Isoforms

α adrenergic receptor β adrenergic receptor

View All 5-HT Receptor Isoform Specific Products:

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

View All Histamine Receptor Isoform Specific Products:

View All Isoforms

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

407.99

Formula

C₂₁H₂₂D₄ClN₃OS

CAS No.

155593-75-2

Unlabeled CAS

58-39-9

Appearance

Solid

Color

White to off-white

SMILES

OCCN(CC1)CCN1CCCN2C3=C([2H])C(Cl)=C([2H])C=C3SC4=CC([2H])=CC([2H])=C42

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (245.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4510 mL	12.2552 mL	24.5104 mL
5 mM	0.4902 mL	2.4510 mL	4.9021 mL
10 mM	0.2451 mL	1.2255 mL	2.4510 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. ;Richtand NM, et al. Dopamine and serotonin receptor binding and antipsychotic efficacy. Neuropsychopharmacology. 2007 Aug;32(8):1715-26. [Content Brief]

[2]. Richtand NM, et al. Dopamine and serotonin receptor binding and antipsychotic efficacy. Neuropsychopharmacology. 2007 Aug;32(8):1715-26. [Content Brief]

[3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	2.4510 mL	12.2552 mL	24.5104 mL	61.2760 mL
	5 mM	0.4902 mL	2.4510 mL	4.9021 mL	12.2552 mL
	10 mM	0.2451 mL	1.2255 mL	2.4510 mL	6.1276 mL
	15 mM	0.1634 mL	0.8170 mL	1.6340 mL	4.0851 mL
	20 mM	0.1226 mL	0.6128 mL	1.2255 mL	3.0638 mL
	25 mM	0.0980 mL	0.4902 mL	0.9804 mL	2.4510 mL
	30 mM	0.0817 mL	0.4085 mL	0.8170 mL	2.0425 mL
	40 mM	0.0613 mL	0.3064 mL	0.6128 mL	1.5319 mL
	50 mM	0.0490 mL	0.2451 mL	0.4902 mL	1.2255 mL
	60 mM	0.0409 mL	0.2043 mL	0.4085 mL	1.0213 mL
	80 mM	0.0306 mL	0.1532 mL	0.3064 mL	0.7660 mL
	100 mM	0.0245 mL	0.1226 mL	0.2451 mL	0.6128 mL