PF-06815345 hydrochloride

Name: PF-06815345 hydrochloride
Brand: MedChemExpress
SKU: HY-112598A
Rating: 4.5 (1 reviews)

Cat. No.: HY-112598A Purity: 98.15%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PF-06815345 hydrochloride is an orally active and potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with an IC₅₀ value of 13.4 μM. PF-06815345 hydrochloride significantly decreases the PCSK9 level in vivo in mouse.

For research use only. We do not sell to patients.

PF-06815345 hydrochloride Chemical Structure

CAS No. : 2334434-49-8

Size	Price	Stock	Quantity
5 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1900	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 3200	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 5000	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PF-06815345 hydrochloride:

PF-06815345 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

PF-06815345 hydrochloride (Example 7) (1-30 μM; 5-1440 min) in human enterocyte and hepatocyte with CL_int values of <82.9 μL/min/mg and 97.6 μL/min/mg, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PF-06815345 hydrochloride (Example 7) (100-500 mg/kg; p.o; single dose) lowers the level of PCSK9 in humanized PCSK9 mouse model. It lowers plasma PCSK9 to 72% at 500 mg/kg 4 hr later treatment^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

634.49

Formula

C₂₇H₃₀Cl₂FN₉O₄

CAS No.

2334434-49-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(N([C@H]1CNCCC1)C2=C(Cl)C=CC=N2)C3=CC=C(C4=C(C5=NN=NN5[C@H](C)OC(OCC)=O)N(C)N=C4)C(F)=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (78.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5761 mL	7.8803 mL	15.7607 mL
5 mM	0.3152 mL	1.5761 mL	3.1521 mL
10 mM	0.1576 mL	0.7880 mL	1.5761 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.15%

Select Batch:

Data Sheet (281 KB) SDS (252 KB)

COA (263 KB) HNMR (112 KB) RP-HPLC (177 KB) LCMS (367 KB)

Handling Instructions (2659 KB)

References

[1]. Akin A, et al. Overcoming the Challenges of Making a Single Enantiomer N-1 Substituted Tetrazole Prodrug Using a Tin-Mediated Alkylation and Enzymatic Resolution[J]. Organic Process Research & Development, 2019, 23(6): 1167-1177.

[2]. Darout E, et al. Preparation of substituted amide compounds as PCSK9 inhibitors: Canada, CA2907071 A1 2016-04-08.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5761 mL	7.8803 mL	15.7607 mL	39.4017 mL
	5 mM	0.3152 mL	1.5761 mL	3.1521 mL	7.8803 mL
	10 mM	0.1576 mL	0.7880 mL	1.5761 mL	3.9402 mL
	15 mM	0.1051 mL	0.5254 mL	1.0507 mL	2.6268 mL
	20 mM	0.0788 mL	0.3940 mL	0.7880 mL	1.9701 mL
	25 mM	0.0630 mL	0.3152 mL	0.6304 mL	1.5761 mL
	30 mM	0.0525 mL	0.2627 mL	0.5254 mL	1.3134 mL
	40 mM	0.0394 mL	0.1970 mL	0.3940 mL	0.9850 mL
	50 mM	0.0315 mL	0.1576 mL	0.3152 mL	0.7880 mL
	60 mM	0.0263 mL	0.1313 mL	0.2627 mL	0.6567 mL