2. Apoptosis PI3K/Akt/mTOR Stem Cell/Wnt JAK/STAT Signaling
  3. Apoptosis PI3K Akt mTOR STAT
  4. PI3K/Akt/mTOR-IN-5

PI3K/Akt/mTOR-IN-5 (compound D3) is a derivative of Pseudolaric Acid B (HY-N6939) with anti-tumor activity. PI3K/Akt/mTOR-IN-5 inhibits excessive proliferation of tumor cells through the PI3K/AKT/mTOR and STAT3/GPX4 pathways. PI3K/Akt/mTOR-IN-5 effectively inhibits EDU positivity, reduces colony formation, places HCT-116 cells in the S phase and G2/M phase, and induces apoptosis.

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PI3K/Akt/mTOR-IN-5 Chemical Structure

PI3K/Akt/mTOR-IN-5 Chemical Structure

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PI3K/Akt/mTOR-IN-5 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

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mTOR mTORC1 mTORC2

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STAT3 STAT5 STAT6 STAT1

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Description

PI3K/Akt/mTOR-IN-5 (compound D3) is a derivative of Pseudolaric Acid B (HY-N6939) with anti-tumor activity. PI3K/Akt/mTOR-IN-5 inhibits excessive proliferation of tumor cells through the PI3K/AKT/mTOR and STAT3/GPX4 pathways. PI3K/Akt/mTOR-IN-5 effectively inhibits EDU positivity, reduces colony formation, places HCT-116 cells in the S phase and G2/M phase, and induces apoptosis[1].

Molecular Weight

542.66

Formula

C30H42N2O7
SMILES

O=C(C1=CC[C@@]([C@@](CC1)(OC(C)=O)[C@]2([H])[C@](/C=C/C=C(C)/C(NCCN3CCCCC3)=O)(C)O4)(CC2)C4=O)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3K/Akt/mTOR-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/Akt/mTOR-IN-5ApoptosisPI3KAktmTORSTATPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinAnti-tumorapoptosiscell cyclederivativesPABHCT-116Inhibitorinhibitorinhibit

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