2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. Pin1 modulator 1

Pin1 modulator 1 (compound IIb-219) is a modulator that specifically targets β-Catenin and inhibits the Wnt pathway. Pin1 modulator 1 can be used in the study of Wnt-mediated related diseases, such as cancer.

For research use only. We do not sell to patients.

Pin1 modulator 1 Chemical Structure

Pin1 modulator 1 Chemical Structure

CAS No. : 301688-74-4

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Description

Pin1 modulator 1 (compound IIb-219) is a modulator that specifically targets β-Catenin and inhibits the Wnt pathway. Pin1 modulator 1 can be used in the study of Wnt-mediated related diseases, such as cancer[1].

Molecular Weight

357.45

Formula

C18H15NO3S2
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(O)CCCN(C/1=O)C(SC1=C\C2=C3C=CC=CC3=CC=C2)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (279.76 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7976 mL 13.9880 mL 27.9759 mL
5 mM 0.5595 mL 2.7976 mL 5.5952 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7976 mL 13.9880 mL 27.9759 mL 69.9398 mL
5 mM 0.5595 mL 2.7976 mL 5.5952 mL 13.9880 mL
10 mM 0.2798 mL 1.3988 mL 2.7976 mL 6.9940 mL
15 mM 0.1865 mL 0.9325 mL 1.8651 mL 4.6627 mL
20 mM 0.1399 mL 0.6994 mL 1.3988 mL 3.4970 mL
25 mM 0.1119 mL 0.5595 mL 1.1190 mL 2.7976 mL
30 mM 0.0933 mL 0.4663 mL 0.9325 mL 2.3313 mL
40 mM 0.0699 mL 0.3497 mL 0.6994 mL 1.7485 mL
50 mM 0.0560 mL 0.2798 mL 0.5595 mL 1.3988 mL
60 mM 0.0466 mL 0.2331 mL 0.4663 mL 1.1657 mL
80 mM 0.0350 mL 0.1748 mL 0.3497 mL 0.8742 mL
100 mM 0.0280 mL 0.1399 mL 0.2798 mL 0.6994 mL
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Pin1 modulator 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pin1 modulator 1301688-74-4Wntβ-cateninBeta cateninHCT-116cancertumorWgInhibitorinhibitorinhibit

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