2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Pizuglanstat

Pizuglanstat  (Synonyms: TAS-205 free base)

Cat. No.: HY-109134 Purity: 99.70%
COA Handling Instructions

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Pizuglanstat (compound 3) is a prostaglandin D synthase inhibitor with an IC50 of 76 nM for human hematopoietic prostaglandin D synthases (H-PGDS). Pizuglanstat can be used for myodegenerative disease research, such as muscular dystrophy.

For research use only. We do not sell to patients.

Pizuglanstat Chemical Structure

Pizuglanstat Chemical Structure

CAS No. : 1244967-98-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 168 In-stock
Solid
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Based on 1 publication(s) in Google Scholar

Other Forms of Pizuglanstat:

Pizuglanstat Related Antibodies

Top Publications Citing Use of Products

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DP EP FP IP TXA2/TP TXB2

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Description

Pizuglanstat (compound 3) is a prostaglandin D synthase inhibitor with an IC50 of 76 nM for human hematopoietic prostaglandin D synthases (H-PGDS). Pizuglanstat can be used for myodegenerative disease research, such as muscular dystrophy[1].

IC50 & Target

DP

 

Molecular Weight

508.61

Formula

C27H36N6O4
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(N1CCOCC1)C2CCN(C3=CC=C(NC(N4CCN(C(C5=CC=CN5C)=O)CC4)=O)C=C3)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (24.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9661 mL 9.8307 mL 19.6614 mL
5 mM 0.3932 mL 1.9661 mL 3.9323 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9661 mL 9.8307 mL 19.6614 mL 49.1536 mL
5 mM 0.3932 mL 1.9661 mL 3.9323 mL 9.8307 mL
10 mM 0.1966 mL 0.9831 mL 1.9661 mL 4.9154 mL
15 mM 0.1311 mL 0.6554 mL 1.3108 mL 3.2769 mL
20 mM 0.0983 mL 0.4915 mL 0.9831 mL 2.4577 mL
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Pizuglanstat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pizuglanstat1244967-98-3TAS-205TAS205TAS 205Prostaglandin ReceptorInhibitorinhibitorinhibit

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