2. Metabolic Enzyme/Protease
  3. Pyruvate Kinase
  4. PKM2 activator 5

PKM2 activator 5 (compound 8) is a PKM2 activator with an AC50 value of 0.316 µM. PKM2 activator 5 has the potential to alter the aberrant metabolism of cancer cells.

For research use only. We do not sell to patients.

PKM2 activator 5 Chemical Structure

PKM2 activator 5 Chemical Structure

CAS No. : 796092-26-7

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5 mg USD 60 In-stock
10 mg USD 90 In-stock
25 mg USD 175 In-stock
50 mg USD 285 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

PKM2 activator 5 (compound 8) is a PKM2 activator with an AC50 value of 0.316 µM. PKM2 activator 5 has the potential to alter the aberrant metabolism of cancer cells[1].

IC50 & Target

PKM2[1].
Molecular Weight

442.48

Formula

C18H19FN2O6S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(N1CCN(S(=O)(C2=CC=C(OCCO3)C3=C2)=O)CC1)(C4=CC=CC(F)=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (113.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2600 mL 11.2999 mL 22.5999 mL
5 mM 0.4520 mL 2.2600 mL 4.5200 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2600 mL 11.2999 mL 22.5999 mL 56.4997 mL
5 mM 0.4520 mL 2.2600 mL 4.5200 mL 11.2999 mL
10 mM 0.2260 mL 1.1300 mL 2.2600 mL 5.6500 mL
15 mM 0.1507 mL 0.7533 mL 1.5067 mL 3.7666 mL
20 mM 0.1130 mL 0.5650 mL 1.1300 mL 2.8250 mL
25 mM 0.0904 mL 0.4520 mL 0.9040 mL 2.2600 mL
30 mM 0.0753 mL 0.3767 mL 0.7533 mL 1.8833 mL
40 mM 0.0565 mL 0.2825 mL 0.5650 mL 1.4125 mL
50 mM 0.0452 mL 0.2260 mL 0.4520 mL 1.1300 mL
60 mM 0.0377 mL 0.1883 mL 0.3767 mL 0.9417 mL
80 mM 0.0282 mL 0.1412 mL 0.2825 mL 0.7062 mL
100 mM 0.0226 mL 0.1130 mL 0.2260 mL 0.5650 mL
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PKM2 activator 5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKM2 activator 5796092-26-7Pyruvate Kinaseaberrant metabolismcancerInhibitorinhibitorinhibit

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